PMID: 2110860Jun 1, 1990Paper

Phase II study of doxorubicin plus ifosfamide/mesna in patients with advanced breast cancer

Cancer
M J MillwardB M Cantwell

Abstract

Four courses of ifosfamide with mesna given by intravenous infusions were combined with bolus doxorubicin in a phase II trial to treat patients with breast cancer. Ifosfamide can deplete intracellular glutathione levels and because doxorubicin resistance may be associated with elevated levels of intracellular glutathione these drugs were combined in an attempt to overcome clinical cytotoxic drug resistance. There were 31 women with poor prognosis advanced breast cancer in the study. Forty-five percent were younger than 40 years old, 68% had visceral dominant disease, 59% had more than two disease sites, and each of the five women tested had increased expression of primary tumor epidermal growth factor receptor. The objective response rate was 71% with manageable toxicity (95% confidence interval, 54% to 85%). The response rate in 22 patients not given prior chemotherapy was 72% and in 9 patients with cancers resistant to previous mitoxantrone monotherapy it was 67%. The high antitumor activity of this combination suggests further exploration of its use in breast cancer.

References

Jul 1, 1986·European Journal of Cancer & Clinical Oncology·C A MeanwellG Blackledge
Jan 1, 1988·Cancer Chemotherapy and Pharmacology·B M CantwellA L Harris
Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·G G StegerK Moser
Apr 1, 1988·Annals of Internal Medicine·K Antman, R P Gale
Jun 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G FalksonF J Cummings
May 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G FalksonF J Pretorius

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Citations

Jan 1, 1994·Breast Cancer Research and Treatment·M MillwardB Cantwell
Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·W P BradeC E Araujo
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A V BoddyJ R Idle
Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H GurneyR Kefford
Nov 13, 2015·International Journal of Cancer. Journal International Du Cancer·Archie BleyerAnthony B Miller
May 3, 2000·Medical Hypotheses·M Wainwright

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