Phase II Study of Haploidentical Natural Killer Cell Infusion for Treatment of Relapsed or Persistent Myeloid Malignancies Following Allogeneic Hematopoietic Cell Transplantation

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Brian C ShafferKatharine C Hsu

Abstract

We conducted a phase 2 study to determine the efficacy of HLA-haploidentical related donor natural killer (NK) cells after cyclophosphamide-based lymphodepletion in patients with relapsed or progressive acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS) following allogeneic hematopoietic cell transplantation (HCT). Eight patients (2 with MDS and 6 with AML) were treated with cyclophosphamide 50 mg/kg on day -3 and day -2 before infusion of NK cells isolated from a haploidentical related donor. One patient also received fludarabine 25 mg/m2/day for 4 days. Six doses of 1 million units of interleukin-2 (IL-2) were administered on alternating days beginning on day -1. The median number of NK cells infused was 10.6 × 10(6)/kg (range, 4.3 to 22.4 × 10(6)/kg), and the median number of CD3 cells infused was 2.1 × 10(3)/kg (range, 1.9 to 40 × 10(3)/kg). NK infusions were well tolerated, with a median time to neutrophil recovery of 19 days (range, 7 days to not achieved) and no incidence of graft-versus-host disease after NK infusion. One patient with AML and 1 patient with MDS achieved a complete response, but relapsed at 1.7 and 1.8 months, respectively. One patient with MDS experienced resolution of dysplastic feature...Continue Reading

References

Mar 13, 2001·Annual Review of Immunology·D H RauletC W McMahon
Oct 7, 2003·Nature Medicine·Valerie RubioPeter P Lee
Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonUNKNOWN International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards
Mar 31, 2004·The Journal of Experimental Medicine·Petra WolintAnnette Oxenius
Nov 6, 2004·Blood Cells, Molecules & Diseases·Ulrike KoehlDirk Schwabe
Oct 6, 2005·The Journal of Experimental Medicine·Yenan T BrycesonEric O Long
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph H ChewningBo Dupont
Apr 23, 2009·Cancer Research·Hiroyuki FujisakiDario Campana
Aug 4, 2010·Cancer Immunology, Immunotherapy : CII·Veronika BachanovaJeffrey S Miller
Nov 19, 2010·Expert Review of Hematology·A John Barrett, Minoo Battiwalla
Aug 31, 2012·The New England Journal of Medicine·Jeffrey M VenstromKatharine C Hsu
Dec 25, 2013·Immunology and Cell Biology·Philip H KruseEric Vivier

❮ Previous
Next ❯

Citations

Aug 18, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Inpyo ChoiKyoo-Hyung Lee
Mar 16, 2018·Future Oncology·Amanda PrzespolewskiEunice S Wang
Aug 30, 2017·International Journal of Molecular Sciences·Beatriz Martín-AntonioAlvaro Urbano-Ispizua
Apr 19, 2018·HLA : Immune Response Genetics·N Kumar, S I Khakoo
Jan 11, 2019·Leukemia & Lymphoma·Hongbing MaYuping Gong
Jun 20, 2019·International Journal of Molecular Sciences·Ramona RotoloDario Sangiolo
Feb 6, 2020·American Journal of Hematology·Cole Sterling, Jonathan Webster
May 18, 2020·Stem Cells Translational Medicine·May Sabry, Mark W Lowdell
Sep 8, 2020·Bioscience Trends·Jufeng XiaKazuma Kuwabara
Mar 3, 2018·Frontiers in Immunology·Rohtesh S Mehta, Katayoun Rezvani
Jun 1, 2018·Journal of Immunology Research·Melissa Mavers, Alice Bertaina
Jul 27, 2018·Frontiers of Medicine·Fang FangZhigang Tian
Feb 26, 2019·Frontiers in Oncology·Gaurav NayyarMitchell S Cairo
Aug 20, 2019·Immunotherapy·Faezeh GhaemdoustNima Rezaei
Jan 8, 2020·Nature Reviews. Drug Discovery·Noriko ShimasakiDario Campana
Apr 2, 2020·Cancers·Kanako ShimizuAnd Shin-Ichiro Fujii
Aug 6, 2020·Cancers·S Elizabeth FranksJames W Hodge
Dec 4, 2016·Hematology·Rohtesh S Mehta, Katayoun Rezvani
Sep 1, 2019·International Journal of Molecular Sciences·Peter ValentDominik Wolf
Dec 3, 2017·International Journal of Hematology·Catharina H M J Van Elssen, Stefan O Ciurea
Apr 22, 2020·Nature Reviews. Clinical Oncology·Bruce R BlazarWilliam J Murphy
May 26, 2018·Bone Marrow Transplantation·Katharina FleischhauerBronwen E Shaw
Sep 6, 2019·International Journal of Molecular Sciences·Tom HoflandSanne H Tonino
Jun 18, 2020·Stem Cell Research & Therapy·Keerthana ShankarKrishanu Saha
Dec 9, 2020·Journal of Hematology & Oncology·Jing Xu, Ting Niu
Oct 28, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·JongBok LeeLi Zhang
Jan 19, 2021·Oncoimmunology·Lisa Marie ReindlEvelyn Ullrich
Oct 31, 2020·Cancers·Mireia BachillerBeatriz Martín-Antonio
Oct 31, 2020·Signal Transduction and Targeted Therapy·Yuqing CaoFeng Xu
Apr 24, 2021·Cancer Gene Therapy·Rakan El-MaytaMichael J Mitchell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.