Phase II study of hepatic arterial infusion of a fine-powder formulation of cisplatin for advanced hepatocellular carcinoma

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Masaharu YoshikawaHironobu Nakamura

Abstract

Intra-arterial cisplatin appears to have high therapeutic efficacy, but this has not been studied in detail. Accordingly, we developed a fine-powder cisplatin formulation and tested it in advanced hepatocellular carcinoma (HCC) patients in an open-label, uncontrolled study in which 27 institutions participated. The patients in this study had inoperable advanced HCC without extrahepatic metastases. All received two infusions of high-concentration cisplatin (1.43 mg/mL) via the hepatic artery at a dose of 65 mg/m(2), with an intervening 4-6 week interval. Cisplatin efficacy and safety were assessed in 80 patients. We found partial responses in 27 cases, no change in 37, and progressive disease in 11 (five were not evaluated). The overall response rate was 33.8%. The 1-year survival rate was 67.5% and the 2-year survival rate was 50.8%. Severe adverse effects (>/=grade 3) included anorexia in 22.5%, vomiting in 6.3%, abdominal pain in 1.3%, thrombocytopenia in 25%, neutropenia in 13%, leukopenia in 1.3%, hypochromia in 1.3%, elevated serum aspartate aminotransferase in 32.5%, elevated serum alanine aminotransferase in 11.3%, elevated serum bilirubin in 3.8%, decreased serum albumin in 1.3%, elevated serum alkaline phosphatase in 1...Continue Reading

References

Dec 1, 1988·European Journal of Cancer & Clinical Oncology·T YoshidaY Shimada
Apr 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F A ShepherdK I Pritchard
Dec 9, 1997·Japanese Journal of Clinical Oncology·H NagahamaM Yoshimori
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R S Go, A A Adjei
Feb 5, 2000·Cardiovascular and Interventional Radiology·K YamamotoI Narabayashi
Mar 23, 2000·Journal of Hepatology·K Okuda
Aug 29, 2002·Cancer Investigation·Wayne S CourtLouis S Zeiger
Oct 28, 2004·Gastroenterology·Brian I Carr

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Citations

Jun 17, 2010·Cardiovascular and Interventional Radiology·Shinichi OhtaKiyoshi Murata
May 18, 2011·Cardiovascular and Interventional Radiology·Shobu WatanabeKiyoshi Murata
Sep 10, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sung Gwe AhnKyung Sik Kim
Apr 11, 2013·Cancer Biotherapy & Radiopharmaceuticals·Liang GuoHong Zhong
Apr 17, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T IshikawaT Yoshida
Apr 1, 2013·Clinical Journal of Gastroenterology·Kazuhiro Nouso
Jan 3, 2012·Journal of Vascular and Interventional Radiology : JVIR·Noboru MaedaNoriyuki Tomiyama
Apr 27, 2010·Journal of Vascular and Interventional Radiology : JVIR·Noboru MaedaHironobu Nakamura
Feb 1, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kenya YamanakaShinji Uemoto
Jan 15, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masamichi MoriguchiMasashi Fujii
Apr 5, 2016·Biological & Pharmaceutical Bulletin·Junya HashizumeHitoshi Sasaki
Sep 10, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kazuto TajiriToshiro Sugiyama
Jul 13, 2016·Clinical Journal of Gastroenterology·Michihisa MoriguchiYoshito Itoh
Oct 30, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M IkedaT Okusaka
Dec 19, 2017·Japanese Journal of Clinical Oncology·Masafumi IkedaJunji Furuse
Mar 20, 2018·Bioscience Trends·Tokio HigakiTadatoshi Takayama
Oct 31, 2009·World Journal of Hepatology·Toru Ishikawa
Mar 22, 2014·The Korean Journal of Internal Medicine·Myeong Jun Song, Si Hyun Bae
Aug 7, 2017·Oncology Letters·Elena Díaz-RodríguezAtanasio Pandiella
Aug 22, 2017·World Journal of Hepatology·Marco Le GrazieAndrea Galli

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