Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia

Cancer
C Patrick BurnsElectra Paskett

Abstract

The authors undertook a multiinstitutional Phase II cooperative group study to examine the potential of oral fish oil fatty acid supplements administered at high doses to slow weight loss and to improve quality of life in patients with malignancy-related cachexia. Patients with advanced malignancy and weight loss > or = 2% of body weight in the preceding month took concentrated, high-dose omega-3 fatty acid capsules (7.5 g eicosapentaenoic acid plus docosahexaenoic acid for a 70 kg individual) that were supplied by the National Institutes of Health. Forty-three patients with moderate or severe malnutrition were enrolled. The median time receiving treatment was 1.2 months. For the 36 patients who took at least 1 capsule and did not have edema, there was a weight change ranging from -6.2 kg to +3.5 kg and an overall median weight loss of 0.8 kg. Twenty-four patients had weight stabilization (a gain of < or = 5% or a loss of < 5%), 6 patients gained > 5% of their body weight, and 6 patients lost > or = 5% of their body weight. There was marked variability in the tolerability of the capsules, and many patients had gastrointestinal side effects. There was a correlation between time receiving treatment and weight gain for the 22 pati...Continue Reading

References

Jan 1, 1977·JPEN. Journal of Parenteral and Enteral Nutrition·G L BlackburnM F Smith
Jun 1, 1990·Nutrition Reviews·C P Burns, A A Spector
Jul 4, 1990·Journal of the National Cancer Institute·C L LoprinziL H Geeraerts
Jan 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C L LoprinziM D Jensen
Feb 22, 1996·Nature·P TodorovM Tisdale
Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P SimonsE F Wouters
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F De ConnoA Caraceni
Jun 13, 2001·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·J M RibaudoW T Leslie
Aug 22, 2002·British Journal of Cancer·S T Russell, M J Tisdale
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eduardo BrueraVickie Baracos

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Citations

May 1, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lenka A TaylorUlrich Massing
Jun 26, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sally WheelwrightColin D Johnson
Nov 26, 2011·The British Journal of Nutrition·Concetta FinocchiaroRosa A Canuto
Nov 3, 2005·Nature Clinical Practice. Oncology·Alessandro LavianoFilippo Rossi-Fanelli
Feb 3, 2012·Nutrition and Cancer·Juliana de Aguiar Pastore SilvaTânia Silvia Frode
Jun 26, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jessica RoyAldebaran M Hofer
Oct 10, 2014·The Cancer Journal·Erin R Alesi, Egidio del Fabbro
Aug 8, 2008·Current Opinion in Supportive and Palliative Care·Florian Strasser
Dec 20, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Benjamin Drew RockettSaame Raza Shaikh
Jan 28, 2012·Seminars in Oncology Nursing·Debra L Barton, Deirdre R Pachman
Aug 17, 2010·Seminars in Oncology·Norleena P GullettOmer Kucuk
Jul 22, 2008·Hematology/oncology Clinics of North America·Mary L Hardy
May 16, 2008·Cancer Letters·Isabelle M BerquinYong Q Chen
Nov 13, 2015·Future Oncology·Ali ArshadAshley Dennison
Oct 26, 2007·Brain Research Reviews·Akhlaq A FarooquiTahira Farooqui
Jul 3, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Thais Martins de LimaRui Curi
Oct 24, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M J Tisdale
Feb 6, 2009·Pediatric Blood & Cancer·Scott D M Miller, Patrick J Mansky
Oct 27, 2006·International Journal of Cancer. Journal International Du Cancer·Alessandra FoladorLuiz C Fernandes
May 16, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J ArendsUNKNOWN ESPEN (European Society for Parenteral and Enteral Nutrition)
Oct 27, 2016·Current Opinion in Supportive and Palliative Care·Alessandro LavianoAngela Koverech
Jul 21, 2016·Journal of the Academy of Nutrition and Dietetics·Kyle L ThompsonTami Piemonte
Jul 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kenneth C H FearonGordon D Murray
Jan 27, 2007·The Cochrane Database of Systematic Reviews·A DeweyI Johnson
Apr 6, 2007·The British Journal of Nutrition·Ramón ColomerCésar Casimiro
Mar 25, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Rafat SiddiquiGary P Zaloga
Mar 25, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Michael J Tisdale
Jul 22, 2019·Healthcare·Toni MitchellKaren S Bishop
Jul 28, 2019·Expert Opinion on Investigational Drugs·Alessio MolfinoMaurizio Muscaritoli

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