PMID: 9525819Apr 3, 1998Paper

Phase II study of intracarotid or selective intracerebral infusion of cisplatin for treatment of recurrent anaplastic gliomas

Journal of Neuro-oncology
E J DropchoR B Morawetz

Abstract

To assess the response of patients with recurrent malignant gliomas to intra-arterial (IA) cisplatin. Eligibility criteria included patients with recurrent supratentorial malignant gliomas and measurable, unilateral contrast-enhancing tumor located within the territory of one or two major cerebral arteries. Patients received 75 mg/m2 IA cisplatin every four weeks. Depending on individual patients' tumor topography, cisplatin was infused either into the cervical internal carotid artery (ICA) (15 patients), or into one or two major cerebral arteries (26 patients), most often the M1 segment of the middle cerebral artery. Of 40 patients evaluable for tumor response, four patients (10%) were responders and nine patients (22%) had disease stabilization. The median time to tumor progression among the 13 patients with tumor response or stable disease was 23.7 weeks. The response rate did not significantly differ between patients receiving ICA versus selective intracerebral infusion, although the latter group contained a higher proportion of glioblastoma. Tumor progression occurred solely as local failure in 33 patients (82%), with all enhancing tumor still located within the vascular territory infused with IA cisplatin. Ipsilateral vis...Continue Reading

Citations

Sep 4, 2003·The Cancer Journal·Ian F Parney, Susan M Chang
Jun 11, 2008·Current Neurology and Neuroscience Reports·Jaishri Blakeley
Nov 5, 2010·Arquivos de neuro-psiquiatria·Eberval Gadelha FigueiredoManoel Jacobsen Teixeira
Mar 3, 2015·Neurosurgical Focus·Benjamin K HendricksJames C Miller
Apr 14, 2015·BioMed Research International·Arijit BhowmikMrinal Kanti Ghosh

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