Phase II study of irinotecan combined with mitomycin-C for advanced or recurrent squamous cell carcinoma of the uterine cervix: the JGOG study

Gynecologic Oncology
Naohiko UmesakiJapan Gynecologic Oncology Group

Abstract

The efficacy and toxicity of combined therapy with irinotecan (CPT-11) plus mitomycin-C (MMC) were evaluated in patients with advanced or recurrent squamous cell carcinoma (SCC) of the uterine cervix. CPT-11 (100 mg/m(2)) was administered on days 1, 8, and 15 by intravenous (iv) infusion over 90 min, while MMC (10 mg/m(2) iv) was given on day 1. This regimen was repeated every 28 days and at least two courses were given. Among 51 eligible patients (median age: 52 years; range: 25-72 years), 2 showed complete response (CR) and 24 showed PR, for an overall response rate (ORR) of 51.0% (95% confidence interval: 36.6-65.3%). In patients without prior chemotherapy, the ORR was 54.8% (38.7-70.2%). Twenty-five patients (Ib2:3, IIb:17, and IIIb:5) received this regimen as neoadjuvant chemotherapy and their ORR was 76% (54.9-90.6%). Twenty-two patients were able to undergo radical surgery after NAC. The major toxicity was neutropenia, which was grade 3-4 in 59% of the patients. Grade 3-4 thrombocytopenia and anemia were also seen in 26% of the patients each. The most common nonhematologic toxicity was diarrhea (grade 3-4 in 12%). CPT-11 combined with MMC can be effective against advanced or recurrent SCC of the uterine cervix.

References

Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·Y KanoY Miura
Mar 1, 1989·Journal of the National Cancer Institute·E J BuxtonD M Luesley
Sep 1, 1986·Annals of Internal Medicine·R Simon
Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Mar 16, 1994·Journal of the National Cancer Institute·D AbigergesD Gandia
Jun 19, 2001·American Journal of Clinical Oncology·M A Gil-DelgadoD Khayat
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierluigi Benedetti-PaniciFabio Landoni
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey D BlossJo Benda

❮ Previous
Next ❯

Citations

Jan 10, 2013·Investigational New Drugs·Mazin F Al-KasspoolesKatherine F Roby
Jun 26, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T MoriH Honjo
Jun 26, 2012·Cancer Treatment Reviews·Giannis MountziosChristos A Papadimitriou
May 20, 2009·Cancer·Sujana MovvaClaire Verschraegen
Sep 1, 2006·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hirohiko TanakaAkinori Ishihara
Aug 23, 2005·Cancer Chemotherapy and Biological Response Modifiers·Max KreditorHoward S Hochster
Aug 6, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Taisuke MoriJo Kitawaki
Aug 12, 2005·Current Opinion in Oncology·Luis A Rojas-Espaillat, Peter G Rose
Jul 1, 2010·Experimental and Therapeutic Medicine·Shoji KakuTakashi Murakami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Wells A MessersmithManuel Hidalgo
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Thierry AndréAimery de Gramont
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Richard M GoldbergSteven R Alberts
© 2021 Meta ULC. All rights reserved