Phase II study of mitomycin, ifosfamide and cisplatin in adenocarcinoma of the oesophagus

Cancer Chemotherapy and Pharmacology
S M AllenH R Matthews

Abstract

We evaluated the effect of brief neoadjuvant chemotherapy in patients with apparently operable adenocarcinoma of the oesophagus. Two courses of mitomycin (6 mg/m2), ifosfamide (3 g/m2) and cisplatin (50 mg/m2;MIC) were given followed by evaluation of response by barium swallow and computed tomography scan. Of 20 patients, 17 completed both courses and 4 (20%) showed a partial response. Toxicity was generally mild and consisted principally of nausea and vomiting. Altogether, 15 patients were surgically explored; resection was completed in 12 patients, 3 of whom died in hospital (25%). Neoadjuvant therapy with MIC offers no advantage over surgery alone.

References

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Jan 1, 1981·Cancer·A B MillerA Winkler

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Citations

Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·T UematsuM Yamaoka
Mar 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yu FangJianguo Hu

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