PMID: 9663665Jul 15, 1998Paper

Phase II study of N-phosphonacetyl-L-aspartate, recombinant interferon-alpha, and fluorouracil infusion in advanced squamous cell carcinoma of the head and neck

Head & Neck
C J LangerJ A Ridge

Abstract

5-Fluorouracil (5-FU), as a single agent, produces a 15% response rate in advanced squamous cell carcinoma of the head and neck (SCCHN). N-phosphonacetyl-L-aspartate (PALA) inhibits pyrimidine biosynthesis and increases incorporation of 5-FU metabolites into ribonucleic acid (RNA). Recombinant alpha interferon-2b (rIFN-alpha-2b) may inhibit 5-FU clearance and blunt reflex rise in thymidylate synthetase, therefore enhancing inhibition of the target enzyme of 5-FU. In an attempt to exploit their potential therapeutic synergy, we initiated a phase II trial combining PALA 250 mg/m2 by intravenous (IV) bolus day 1 with 5-FU 2600 mg/m2 24-hour IV infusion initiated 24 hours after PALA, followed by rIFNalpha-2b 10 million units (MU) by subcutaneous injection days 2, 3, and 4 in patients with advanced, measurable SCCHN incurable with surgery or radiotherapy. Treatment was repeated weekly; patients were assessed every 4-6 weeks. Pretreatment tumor specimens were analyzed for p53 mutations in exons 5-8 and for protein expression using the p53 polyclonal antibody CM-1. Nineteen patients were enrolled from November 1991 through February 1994. Median age was 59 years (range, 31-72 years). All had previously received definitive radiotherapy,...Continue Reading

References

Feb 1, 1992·Seminars in Oncology Nursing·S C McMillan
Aug 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A A ForastiereS K Williamson
Feb 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E E VokesW R Panje
Feb 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C JacobsL Schacter
Oct 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J L GremL J Goldstein
Sep 15, 1989·Biochemical and Biophysical Research Communications·L Elias, J M Sandoval
Jun 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M ConnorsC Jacobs
Jan 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S G Taylor
Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Jun 1, 1995·The Laryngoscope·E R SauterA Klein-Szanto
Oct 1, 1993·Archives of Otolaryngology--head & Neck Surgery·J K FieldJ L Gluckman
Feb 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E E VokesB Wenig
Apr 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L L DanhauserA B Markowitz
Nov 6, 1996·Journal of the National Cancer Institute·W M KochD Sidransky

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