Phase II study of neoadjuvant 5-FU + leucovorin + CPT-11 in patients with resectable liver metastases from colorectal adenocarcinoma

BMC Cancer
Oliver F BatheScott Ernst

Abstract

Following resection of liver metastases from colorectal cancer, 5-year survivals are reportedly 30 - 39%. It can be assumed that this clinical situation represents systemic disease. Therefore, it is postulated that systemic chemotherapy would improve outcomes, particularly in those whose disease is sensitive to the agents administered. One potential advantage of neoadjuvant chemotherapy is that it provides in vivo chemosensitivity data. Response to neoadjuvant chemotherapy could therefore guide adjuvant chemotherapy following resection of liver metastases from colorectal cancer. This is a prospective Phase II evaluation of outcomes in patients with potentially resectable liver metastases. Patients will receive neoadjuvant chemotherapy and will undergo resection. Postoperative chemotherapy will be directed by the degree of response to preoperative chemotherapy. All patients with Stage IV colorectal adenocarcinoma isolated to the liver that have disease that is amenable to complete ablation by resection, radiofrequency ablation, and/or cryoablation will be candidates for the trial. Patients will receive CPT-11 180 mg/m2 IV (over 90 minutes) on day 1 with 5-FU 400 mg/m2 bolus and 600 mg/m2 by 22 hour infusion and calcium folinate ...Continue Reading

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Citations

Sep 18, 2009·Annals of Surgical Oncology·Norikatsu MiyoshiMasaki Mori
Jun 17, 2010·Annals of Surgical Oncology·Norikatsu MiyoshiMasaki Mori
Dec 25, 2009·Annals of Surgical Oncology·Norikatsu MiyoshiMasaki Mori
Dec 2, 2015·Molecular and Clinical Oncology·Norikatsu MiyoshiMasahiko Yano
Mar 1, 2018·Surgery Today·Norikatsu MiyoshiMasahiko Yano
Nov 12, 2009·British Journal of Cancer·N MiyoshiM Mori
Dec 30, 2009·Journal of Surgical Oncology·Norikatsu MiyoshiMasaki Mori
Nov 3, 2005·Journal of Biomedical Materials Research. Part a·Elvin BlancoJinming Gao
Oct 8, 2014·Oncology Letters·Norikatsu MiyoshiMasaki Mori
Oct 3, 2013·Oncology Reports·Miho OkanoHideshi Ishii
Oct 9, 2014·Oncology Letters·Hirofumi YamamotoMasaki Mori

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BETA
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