Phase II study of radiotherapy combined with gemcitabine for locally advanced pancreatic cancer

British Journal of Cancer
T OkusakaH Ikeda

Abstract

Gemcitabine has been reported to be a potent radiosensitiser in human pancreatic cell lines. This study was conducted to evaluate the efficacy and toxicity of radiotherapy combined with gemcitabine for locally advanced pancreatic cancer. In all, 42 patients with pancreatic cancer that was unresectable but confined to the pancreatic region were treated with external-beam radiation (50.4 Gy in 28 fractions over 5.5 weeks) and weekly gemcitabine (250 mg m(-2), 30-min infusion). Maintenance gemcitabine (1000 mg m(-2) weekly x 3 every 4 weeks) was initiated 1 month after the completion of the chemoradiotherapy and continued until disease progression or unacceptable toxicity. Of the 42 patients, 38 (90%) completed the scheduled course of chemoradiotherapy. The major toxicity was leucopenia and anorexia. There was one death attributed to duodenal bleeding and sepsis. The median survival time was 9.5 months and the 1-year survival rate was 28%. The median progression-free survival time was 4.4 months. In 35 patients with documented disease progression at the time of analysis, 34 (97%) showed distant metastasis as the cause of the initial disease progression. The chemoradiotherapy used in this study has a moderate activity against local...Continue Reading

References

Mar 1, 1996·International Journal of Radiation Oncology, Biology, Physics·T S LawrenceD S Shewach
Jul 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D J WagenerJ Wils
Jan 1, 1996·Investigational New Drugs·D S Shewach, T S Lawrence
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Apr 3, 2001·Cancer·T OkusakaUNKNOWN Non-surgical Treatment Group for Pancreatic Cancer in Japan
Aug 3, 2001·International Journal of Radiation Oncology, Biology, Physics·J M PipasR P Perez
Nov 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C J McGinnT S Lawrence
Apr 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Christopher H CraneN A Janjan
Oct 16, 2002·International Journal of Radiation Oncology, Biology, Physics·Matthew M PoggiLaurie L Herscher
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Chung-Pin LiSang-Hue Yen
Dec 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey H MulerMark M Zalupski
Sep 3, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R E N Van RijswijkUNKNOWN EORTC GastroIntestinal Tract Cancer Cooperative Group

❮ Previous
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Citations

Feb 16, 2008·Journal of Hepato-biliary-pancreatic Surgery·Hiroya SaitoUNKNOWN Japan Society of Clinical Oncology
Sep 12, 2008·World Journal of Gastroenterology : WJG·Hisato IgarashiRyoichi Takayanagi
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick J LoehrerAl B Benson
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Vivek Maheshwari, A James Moser
Jul 20, 2011·American Journal of Therapeutics·Karam M Obeid, Anilrudh A Venugopal
Dec 16, 2006·World Journal of Surgery·Ryuichiro DoiShinji Uemoto
May 9, 2008·International Journal of Clinical Oncology·Edgar Ben-Josef, Theodore S Lawrence
May 9, 2008·International Journal of Clinical Oncology·Takuji OkusakaHiroyuki Shinchi
Aug 26, 2009·Journal of Gastroenterology·Akira SawakiKenji Yamao
Feb 27, 2010·Japanese Journal of Clinical Oncology·Hiroshi IshiiUNKNOWN JCOG Gastrointestinal Oncology Study Group
Nov 2, 2011·Journal of Gastroenterology·Takeo ShimasakiYoshiharu Motoo
Sep 21, 2005·Japanese Journal of Clinical Oncology·Hiroshi IshiiMasahiro Yoshino
Nov 9, 2019·Scientific Reports·Akiko TsujimotoTaketo Yamaguchi
May 3, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Hu RenCheng-Feng Wang
Jun 11, 2011·International Journal of Radiation Oncology, Biology, Physics·Anand MahadevanMark Callery

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