PMID: 3383974Apr 1, 1988Paper

Phase II study of the antifolate N10-propargyl-5,8-dideazafolic acid (CB 3717) in advanced breast cancer

European Journal of Cancer & Clinical Oncology
B M CantwellA H Calvert

Abstract

Fifty-two patients with progressive advanced breast cancer were treated with the novel antifolate CB 3717 (N10-propargyl-5,8-dideazofolic acid) which inhibits thymidylate synthetase. Forty-six patients were pretreated with hormones, 43 with cytotoxic chemotherapy and 39 patients with both treatments. Eight of 48 patients (16.6%) evaluable for response had partial responses (confidence limits 7.4-30.2%, 95% confidence level) following CB 3717 administration. Liver function abnormalities, reversible in most cases, were the most commonest toxicities and were frequently accompanied by malaise. Severe renal failure occurred in eight patients, five of whom had had partial responses to CB 3717. This study shows the importance of thymidylate synthetase as a target for therapy but the clinical value of CB 3717 is limited by its hepatic and renal toxicities.

References

Jan 1, 1981·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T R JonesK R Harrap

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Citations

Jan 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R J MaxwellJ R Griffiths
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·B M O'ConnorM S Rhee
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·B MitrovskiC Erlichman
Jul 1, 1988·Irish Journal of Medical Science·B M Cantwell
Jan 1, 1989·Advances in Enzyme Regulation·K R HarrapA H Calvert
Jan 1, 1994·Cancer Investigation·A Jackman, I Judson
Feb 24, 2001·Clinical Pharmacokinetics·S J ClarkeL P Rivory
Aug 1, 1997·Hematology/oncology Clinics of North America·S O'Reilly, E K Rowinsky

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