Phase II study of uracil-tegafur plus cisplatin in patients with previously untreated advanced non-small cell lung cancer

Respirology : Official Journal of the Asian Pacific Society of Respirology
Koichi TakayamaFukuoka Lung Cancer Study Group, Japan

Abstract

A multi-institutional phase II trial combining uracil-tegafur (UFT) and cisplatin (CDDP) was conducted in patients with previously untreated advanced non-small cell lung cancer (NSCLC) to evaluate the safety and efficacy of this combined treatment regimen. The entry criteria for this study were previously untreated NSCLC, measurable disease, age <80 years, performance status <2, and adequate haematological, hepatic and renal function. Patients were treated with 400 mg/m(2) oral UFT from day 1 to day 14 and 80 mg/m(2) cisplatin on day 15. The treatment course was repeated every 3 weeks. Of the 68 patients enrolled, 64 (27 with stage IIIB and 37 with stage IV disease) were eligible for treatment. Twenty of the 64 patients responded to the chemotherapy (response rate 31.3%; 95% CI 21.2-43.4%). The median survival time was 8.6 months, and the 1-year survival was 41.5%. Haematological toxicity >or=WHO grade 3 was seen in 3 (4.7%) patients. For non-haematological toxicities, anorexia with WHO grade 3 was seen in 8 (12.5%) patients, nausea and vomiting with WHO grade 3 in 4 (6.3%), diarrhoea with WHO grade 4 in 1 (1.6%), and liver dysfunction with WHO grade 4 in 1 (1.6%) patient. The combination of oral UFT plus cisplatin was found to...Continue Reading

References

Dec 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W HeimD Alt
Nov 1, 1985·Cancer Treatment Reports·P L WeidenR H Rudolph
Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H WadaT Teramatsu
Feb 13, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J SaitoT Nakabayashi
Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Oct 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Egbert F SmitUNKNOWN European Organization for Research and Treatment of Cancer Lung Cancer Group
Apr 23, 2004·The New England Journal of Medicine·Harubumi KatoUNKNOWN Japan Lung Cancer Research Group on Postsurgical Adjuvant Chemotherapy
Jul 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chikuma HamadaHiromi Wada

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Citations

Feb 5, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Richard Ruffin, Philip G Bardin
Feb 5, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tadashi IgishiEiji Shimizu
Oct 20, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Erin M BertinoMiguel A Villalona-Calero

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