Phase II study of weekly oxaliplatin and 24-h infusion of high-dose 5-fluorouracil and folinic acid in the treatment of advanced gastric cancer

British Journal of Cancer
Y ChaoA L Cheng

Abstract

To investigate the efficacy and safety of combining weekly oxaliplatin with weekly 24-h infusion of high-dose 5-fluorouracil (5-FU) and folinic acid (FA) in treatment of patients with advanced gastric cancer. Patients with histologically confirmed, locally advanced or recurrent/metastatic gastric cancer were studied. Oxaliplatin 65 mg m(-2) 2-h intravenous infusion, and 5-FU 2600 mg m(-2) plus FA 300 mg m(-2) 24-h intravenous infusion, were given on days 1 and 8, repeated every 3 weeks. Between January 2001 through January 2002, 55 patients were enrolled. The median age was 64 years (range: 22-75). In all, 52 patients (94.5%) had recurrent or metastatic disease and three patients had locally advanced disease. Among 50 patients evaluable for tumour response, 28 patients achieved partial response, with an overall response rate of 56% (95% confidence interval (CI): 41.8-70.3%). All 55 patients were evaluated for survival and toxicities. Median time to progression and overall survival were 5.2 and 10.0 months, respectively, during median follow-up time of 24.0 months. Major grades 3-4 toxicities were neutropenia in 23 cycles (7.1%) and thrombocytopenia in 16 cycles (5.0%). Treatment was discontinued for treatment-related toxicities...Continue Reading

References

Apr 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D KelsenM Brennan
Mar 1, 1991·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C LouvetM Krulik
Apr 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B ArdalanL Morrell
Sep 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P PreusserH Buente
Nov 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U VanhoeferS Seeber
Apr 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K H Yeh, A L Cheng
Jan 1, 1993·Cancer Treatment Reviews·M Findlay, D Cunningham
Jan 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D HasencleverV Diehl
Oct 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M YchouH Pujol
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A WebbM Meehan
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I MonnetH de Cremoux
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H Bleiberg
Jun 30, 2000·Journal of Clinical Gastroenterology·R De VivoB Daniele
Aug 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A de GramontA Bonetti
Jan 5, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J L MissetJ Otero
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C KollmannsbergerC Bokemeyer
Nov 8, 2002·Seminars in Oncology·Jim Cassidy, Jean-Louis Misset
Nov 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C LouvetA de Gramont
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi OhtsuUNKNOWN Japan Clinical Oncology Group Study (JCOG9205)
Jan 18, 2003·Cellular and Molecular Life Sciences : CMLS·A M Di FrancescoR Riccardi
Feb 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D Y KimN K Kim
May 30, 2003·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·David M Roder
Sep 10, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C-H KöhneUNKNOWN European Organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952
Feb 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Salah-Eddin Al-BatranElke Jaeger

❮ Previous
Next ❯

Citations

May 1, 2007·Pharmacogenomics·Giuseppe Toffoli, Erika Cecchin
Oct 25, 2011·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Han Jo KimHee Sook Park
Sep 1, 2007·Cancer Research and Treatment : Official Journal of Korean Cancer Association·In Sil ChoiJong-Seok Lee
Apr 1, 2005·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Yeul Hong Kim
Mar 31, 2011·World Journal of Gastroenterology : WJG·Xiao-Dong LiChang-Ping Wu
Feb 17, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L CelioE Bajetta
Jan 26, 2006·Expert Opinion on Investigational Drugs·Kenneth KhamlyJohn Zalcberg
Jan 26, 2006·Journal of Chemotherapy·A Zaniboni, F Meriggi
Oct 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Li ZhangShao-Xiong Wu
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lionel LimTrevor Leong
Jul 7, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter C EnzingerRichard M Goldberg
Nov 3, 2006·Nature Reviews. Drug Discovery·Thomas RückleChristian Rommel
Oct 13, 2005·Current Opinion in Gastroenterology·Trevor Leong
Jan 13, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yo Han ChoSo Young Yoon
Oct 16, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Vincenzo CatalanoGiammaria Fiorentini
Nov 16, 2016·Proceedings. Mathematical, Physical, and Engineering Sciences·P A WhighamM Parry
Jan 19, 2019·Oncology Letters·Honghu XieZhong Guan
May 29, 2013·Cancer Chemotherapy and Pharmacology·Min ShiJun Zhang
Jan 1, 2015·Expert Opinion on Orphan Drugs·Y ShimodairaJ A Ajani
Oct 25, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Shengnan GuoZhitu Zhu
Jun 3, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kazuhiro YoshidaMasahiko Nishiyama

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.