Phase II trial of a trimodality regimen for stage III non-small-cell lung cancer using chemotherapy as induction treatment with concurrent hyperfractionated chemoradiation with carboplatin and paclitaxel followed by subsequent resection: a single-center study

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
G FriedelThomas Hehr

Abstract

PURPOSE We started a phase II trial of induction chemotherapy and concurrent hyperfractionated chemoradiotherapy followed by either surgery or boost chemoradiotherapy in patients with advanced, stage III disease. The purpose is to achieve better survival in the surgery group with minimum morbidity and mortality. PATIENTS AND METHODS Patients treated from 1998 to 2002 with neoadjuvant chemoradiotherapy and surgical resection for stage III NSCLC were analyzed. The treatment consisted of four cycles of induction chemotherapy with carboplatin/paclitaxel followed by chemoradiotherapy with a reduced dose of carboplatin/paclitaxel and accelerated hyperfractionated radiotherapy with 1.5 Gy twice daily up to 45 Gy. After restaging, operable patients underwent thoracotomy. Inoperable patients received chemoradiotherapy up to 63 Gy. Study end points included resectability, pathologic response, and survival. Results One hundred twenty patients were enrolled; 25% patients had stage IIIA, 73% had stage IIIB, and 2% stage IV. After treatment, 47.5% had downstaging, 29.2% had stable disease, and 23.3% had progressive disease. Thirty patients (25%) were not eligible for operation because of progressive disease, stable disease, and/or functional...Continue Reading

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Citations

Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Joaquim Bosch-BarreraIgnacio Gil-Bazo
Jan 12, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Volker StegerThorsten Walles
Jan 8, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Filippo LococoPierluigi Granone
Sep 22, 2012·Interactive Cardiovascular and Thoracic Surgery·Volker StegerThorsten Walles
Feb 6, 2016·General Thoracic and Cardiovascular Surgery·Hiroaki NomoriHiroshi Sugimura
Apr 22, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W E E EberhardtUNKNOWN Panel Members
Jul 13, 2012·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Yasushi ShintaniMitsunori Ohta
Feb 20, 2013·Revue des maladies respiratoires·P Bonnette
Apr 12, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Aalok P PatelVarun Puri
Apr 14, 2012·Asian Cardiovascular & Thoracic Annals·Yasushi ShintaniMitsunori Ohta
Feb 7, 2019·General Thoracic and Cardiovascular Surgery·Hidenao KayawakeTomoaki Matsuoka
Aug 8, 2018·General Thoracic and Cardiovascular Surgery·Hidenao KayawakeTomoaki Matsuoka
Jan 6, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger StuppMiklos Pless
Dec 24, 2010·Current Opinion in Oncology·Paul BaasMichel van den Heuvel
Jan 16, 2021·General Thoracic and Cardiovascular Surgery·Özgür İşgörücü, Necati Citak
Jun 10, 2021·Türk göğüs kalp damar cerrahisi dergisi·Mustafa Vedat DoğruMuzaffer Metin

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