PMID: 10837957Jun 6, 2000Paper

Phase II trial of adjuvant radiation and intraperitoneal 5-fluorouracil for locally advanced colon cancer: results with 10-year follow-up

International Journal of Radiation Oncology, Biology, Physics
J A PalermoA W Blackstock


To determine the toxicity, disease-free survival, and overall survival for patients with Modified Astler-Coller (MAC) B2-3 or C1-3 colon cancer receiving adjuvant radiation and sequential intraperitoneal 5-fluorouracil (5-FU). From August 1984 to June 1989, 45 patients were accrued to this Phase II trial and received a 21-week course of intraperitoneal 5-FU (20 mg/kg/d x 5) and external beam radiation. The radiation was delivered to the tumor bed and para-aortic lymph nodes in two split-courses of 22.5 Gy, alternating with the first two cycles of chemotherapy. All patients then received 4 additional cycles of intraperitoneal 5-FU. The therapy was well tolerated with 4 patients experiencing Grade 3 peritonitis. Four patients developed small bowel obstruction requiring surgery; in each instance, recurrent tumor was found at the time of laparotomy. The median and overall survivals at 10 years were 9.3 months and 53% respectively. Local failures were infrequent, occurring in only 11% of patients treated. Sequential intraperitoneal 5-FU and tumor-bed/para-aortic irradiation is tolerable in patients with resected colon cancer. Although the incidence of local and regional relapse appeared to be lower than anticipated, this did not app...Continue Reading


Aug 15, 1991·The New England Journal of Medicine
Mar 14, 1991·The New England Journal of Medicine·J E KrookJ A Mailliard
Feb 8, 1990·The New England Journal of Medicine·C G MoertelJ H Glick
Jun 6, 1985·The New England Journal of Medicine·Gastrointestinal Tumor Study Group
Jan 1, 1985·International Journal of Nuclear Medicine and Biology·R E GibsonR Eng
Dec 1, 1988·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P R Thomas, A S Lindblad
Mar 2, 1988·Journal of the National Cancer Institute·N WolmarkW Lawrence
May 1, 1986·Gynecologic Oncology·C D RunowiczC J Cohen
Apr 1, 1985·International Journal of Radiation Oncology, Biology, Physics·L L GundersonS Levitt
Mar 22, 1984·The New England Journal of Medicine·Gastrointestinal Tumor Study Group
May 1, 1984·International Journal of Radiation Oncology, Biology, Physics·C WillettG Donaldson
Aug 9, 1984·The New England Journal of Medicine
Jan 1, 1997·International Journal of Radiation Oncology, Biology, Physics·S E SchildH Nelson
Sep 1, 2008·Journal of Oncology Practice·William R RobinsonCarrie Ballard


Jul 31, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D A M SloothaakPieter J Tanis
Jan 6, 2017·Future Oncology·Maximiliano GelliDiane Goéré
Dec 8, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Paul L FeingoldUdo Rudloff
Mar 1, 2007·Neurosurgery·Gregory P Lekovic, Timothy R Harrington

Related Concepts

Antimetabolites, Antineoplastic
Malignant Tumor of Colon
5-FU medac
Parenteral Infusion
Malignant Neoplasm of Liver
Lymphatic Metastasis
TNM Staging System
Secondary Peritonitis
Progression-Free Survival
Radiotherapy, Adjuvant

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