Phase II trial of brachytherapy alone after lumpectomy for select breast cancer: toxicity analysis of RTOG 95-17

International Journal of Radiation Oncology, Biology, Physics
Robert R KuskeRaymond M Wilenzick

Abstract

Accelerated partial breast irradiation (APBI) can be delivered with brachytherapy within 4-5 days compared with 5-6 weeks for conventional whole breast external beam radiotherapy. Radiation Therapy Oncology Group 95-17 is the first prospective phase I-II cooperative group trial of APBI alone after lumpectomy in select patients with breast cancer. The toxicity rates are reported for low-dose-rate (LDR) and high-dose-rate (HDR) APBI on this trial. The inclusion criteria for this study included invasive nonlobular tumors < or =3 cm after lumpectomy with negative surgical margins and axillary dissection with zero to three positive axillary nodes without extracapsular extension. The patients were treated with either LDR APBI (45 Gy in 3.5-5 days) or HDR APBI (34 Gy in 10 twice-daily fractions within 5 days). Chemotherapy (> or =2 weeks after APBI) and/or tamoxifen could be given at the discretion of the treating physicians. Between August 1997 and March 2000, 100 women were enrolled in this study, and 99 were evaluated. Of the 99 women, 33 were treated with LDR and 66 with HDR APBI. The median follow-up for all patients was 2.7 years (range, 0.6-4.4 years) and was 2.9 years for LDR and 2.7 years for HDR patients. Toxicities attribut...Continue Reading

References

Oct 20, 1993·International Journal of Radiation Oncology, Biology, Physics·F ViciniA Martinez
Aug 5, 1999·Hematology/oncology Clinics of North America·R R Kuske
Apr 24, 2001·International Journal of Radiation Oncology, Biology, Physics·D E WazerT A DiPetrillo
May 23, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R Camidge, A Price
Jul 4, 2002·International Journal of Radiation Oncology, Biology, Physics·David E WazerThomas A DiPetrillo
Feb 20, 2003·Journal of the National Cancer Institute·Charles Bankhead
Jun 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Douglas W ArthurRupert K Schmidt-Ullrich
Aug 21, 2003·Journal of the National Cancer Institute·Frank A ViciniAlvaro Martinez
Apr 6, 2004·Brachytherapy·Douglas W ArthurUNKNOWN American Brachytherapy Society

❮ Previous
Next ❯

Citations

Mar 28, 2008·Current Oncology Reports·Todd A Swanson, Frank A Vicini
Sep 23, 2008·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Ken YoshidaKeiko Kuriyama
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·Oscar E StreeterKristin A Skinner
May 31, 2007·Nature Clinical Practice. Oncology·Rajiv Sarin, Supriya Chopra
May 1, 2013·Nature Reviews. Clinical Oncology·John A Cox, Todd A Swanson
Dec 20, 2011·Journal of the National Cancer Institute·Jona A HattangadiRinaa S Punglia
Sep 22, 2006·Current Opinion in Oncology·Erik Van Limbergen, Caroline Weltens
Mar 7, 2013·Annals of Surgical Oncology·Mitchel BarryMonica Morrow
Feb 2, 2012·International Journal of Breast Cancer·Norman R WilliamsMohammed R S Keshtgar
Apr 29, 2009·International Journal of Radiation Biology·Christina SkourouKeith D Paulsen
Mar 15, 2016·International Journal of Radiation Oncology, Biology, Physics·Jinhai HuoGrace L Smith
Jul 7, 2011·Clinical Breast Cancer·David A BushJames M Slater
Jun 7, 2011·International Journal of Radiation Oncology, Biology, Physics·Alan A LewinCristiane Takita
Mar 29, 2011·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Mira M ShahLawrence B Marks
Mar 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Rafael Martínez-MongeMatías Jurado
Jun 1, 2010·International Journal of Radiation Oncology, Biology, Physics·Christine E Hill-KayserLawrence J Solin
Dec 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Tzu-I J YangCorine van Vliet-Vroegindeweij
Oct 9, 2009·International Journal of Radiation Oncology, Biology, Physics·Tzu-I J YangCorine van Vliet-Vroegindeweij
Jun 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Benjamin D SmithJay R Harris
Jul 28, 2009·Journal of the American College of Surgeons·Benjamin D SmithJay R Harris
Oct 22, 2008·International Journal of Radiation Oncology, Biology, Physics·Jean-Philippe PignolCarole Chartier
Oct 29, 2008·Brachytherapy·James H BrashearsJoseph M Jenrette
Sep 12, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Birgitte V OffersenJens Overgaard
Oct 7, 2008·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J-M Hannoun-LeviS Marcié
Jul 22, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C AristeiA Rulli
Jun 3, 2008·International Journal of Radiation Oncology, Biology, Physics·Robert A Cormack, Phillip M Devlin
Nov 27, 2007·International Journal of Radiation Oncology, Biology, Physics·Laurie W CuttinoDouglas W Arthur
Aug 21, 2007·International Journal of Radiation Oncology, Biology, Physics·Ross P PetersenIvo A Olivotto
May 15, 2007·The Surgical Clinics of North America·Regina M FearmontiHenry M Kuerer
Mar 17, 2007·International Journal of Radiation Oncology, Biology, Physics·Richard PötterUNKNOWN Austrian Breast and Colorectal Cancer Study Group
Jan 27, 2007·Current Problems in Cancer·Gregory M Chronowski, Thomas A Buchholz
Feb 22, 2011·Journal of Surgical Oncology·Peter D BeitschFrank A Vicini
Sep 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Elaine K WongIvo A Olivotto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.