Abstract
We assessed the safety and efficacy of docetaxel, a microtubule inhibitor, in patients with advanced hepatocellular carcinoma (HCC). HCC patients that were not suitable for local therapy, but who possessed measurable disease, good performance status and adequate organ function were eligible. Docetaxel was administered every 3 weeks at a dose of 100 mg/m(2) (or 75 mg/m(2) if transaminase levels were between 1.5 and 3.5 times the upper normal limit). Efficacy was assessed radiologically every three cycles of chemotherapy. Fifteen patients were enrolled: 11 males and 4 females; their median age was 64 years (range, 42-72 years). Nine patients had underlying cirrhosis. Four patients had been surgically treated before relapse (liver resection in 3 cases and transplantation in 1), 3 had been treated with arterial chemoembolization and 1 with arterial chemotherapy (doxorubicin). A total of 57 cycles of docetaxel were delivered (median 3, range 1-6). Significant toxicity was observed: mostly grade 3-4 neutropenia and fatigue (6 and 4 patients, respectively). Treatment had to be stopped because of toxicity in 6 patients, all having underlying cirrhosis. An important partial response was obtained in 1 patient, a result that enabled liver...Continue Reading
References
May 1, 1977·Cancer·C L VogelJ L Ziegler
Oct 1, 1975·Cancer·C L OlwenyH Cohen
Dec 15, 1980·Cancer·C L OlwenyS K Kyalwazi
Jan 1, 1997·Investigational New Drugs·J G WallJ S Macdonald
Jun 13, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M G DonelliA Crosignani
Jul 14, 1998·British Journal of Cancer·Y ChaoS D Lee
Aug 6, 1998·Alimentary Pharmacology & Therapeutics·P MathurinT Poynard
Mar 27, 1999·Clinical Pharmacokinetics·S J Clarke, L P Rivory
Feb 3, 2000·Journal of the National Cancer Institute·P TherasseS G Gwyther
Jul 25, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R E ColemanD W Miles
Aug 30, 2000·Cancer·H L LinC W Chi
Oct 29, 2000·Oncology·M LencioniP F Conte
Jan 10, 2001·Cancer·E M O'ReillyL B Saltz
Feb 24, 2001·Clinics in Liver Disease·H B el-Serag
Jun 16, 2001·Oncology·H Ulrich-PurW Scheithauer
Sep 5, 2002·Cancer·Hao ZhangKyosuke Yamamoto
Apr 8, 2003·World Journal of Gastroenterology : WJG·Chang-Xin GengJi-Yao Wang
Dec 12, 2003·Cancer·Julien TaïebValerie Boige
May 8, 2004·The Cancer Journal·Mike Cusnir, Yehuda Z Patt
Jun 16, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anna K NowakMichael Findlay
Nov 3, 2004·Journal of Hepatology·Andreas P SutterHans Scherübl
Dec 22, 2004·Journal of Gastroenterology and Hepatology·Toru IshikawaHitoshi Asakura
Jan 8, 2005·Cancer·Masafumi IkedaChigusa Morizane
Apr 15, 2005·Journal of Gastroenterology·Josep M Llovet
Citations
Nov 19, 2011·International Journal of Clinical Oncology·Ryoichi YanoMikio Masada
Oct 14, 2011·Future Oncology·Qian ZhouWinnie Yeo
Oct 23, 2009·Biomaterials·Zhenghong XuYaping Li
Oct 27, 2009·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Koushiro OhtsuboNorio Sawabu
Oct 15, 2008·Biomaterials·Zhenghong XuYaping Li
Apr 17, 2008·Cancer·Amani AsnaciosJulien Taieb
Jul 12, 2007·Cancer·Melanie B ThomasJames L Abbruzzese
Mar 3, 2007·Cancer·Samy LouafiJulien Taïeb
Jan 15, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yutaka YataToshiro Sugiyama
Sep 20, 2012·Journal of Hepatology·Aziz ZaananJulien Taïeb
Feb 26, 2015·International Journal of Clinical Oncology·Ying LiuJufeng Wang
Nov 12, 2013·Journal of the Egyptian National Cancer Institute·Omar Abdel-Rahman
Sep 26, 2008·The Korean Journal of Hepatology·Ki Tae YoonDo Young Kim
Jul 28, 2007·Oncology·Tony S K MokCesar Wong
Jun 25, 2016·Oncotarget·Xixi ChenJianing Zhang
Jun 7, 2017·Journal of Zhejiang University. Science. B·Lan-Lan WanLi-Qun Ren
Jun 18, 2020·AAPS PharmSciTech·Pawan TekchandaniShivani Rai Paliwal
Dec 3, 2020·Molecular Pharmaceutics·Rostislav A PetrovAlexander G Majouga