Jul 1, 1989

Phase II trial of fludarabine phosphate in advanced renal cell carcinoma: an Illinois Cancer Council Study

Investigational New Drugs
D H ShevrinN J Vogelzang

Abstract

Fludarabine Phosphate (FP), the 2-fluoro, 5'phosphate derivative of adenosine arabinoside (ara-A), was studied in 18 patients with advanced renal cell carcinoma. These patients had measurable disease and had not received chemotherapy. FP was administered at a loading dose of 20 mg/m2 followed by a 48-hour infusion at 30 mg/m2/day given every 21 days. There were no complete or partial responses seen. Toxicity was mainly hematologic, with leukopenia most commonly observed. FP given in this manner had no activity in advanced renal cell carcinoma.

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Mentioned in this Paper

Arabinonucleotides
Hematology (Discipline)
Adenosine
Antimetabolites, Antineoplastic
Neoplasms
Phosphate Measurement
Fludara
Leukopenia
Drug Evaluation
Chromophobe Renal Cell Carcinoma

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