Phase II trial of gemcitabine/carboplatin followed by paclitaxel in patients with performance status=2,3 or other significant co-morbidity (HIV infection or s/p organ transplantation) in advanced non-small cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Benjamin B BridgesMartin J Edelman

Abstract

The role of chemotherapy in patients with advanced non-small cell lung cancer and poor performance status or who have HIV disease or organ transplantation is unclear. While survival appears to be enhanced, serious toxicity may occur. We evaluated the efficacy of sequential, dose attenuated carboplatin/gemcitabine followed by paclitaxel in patients with PS=2,3, HIV infection or after solid organ transplantation. Chemotherapy naive patients with PS 2,3 or who were HIV positive or post solid organ transplantation were eligible. Treatment consisted of gemcitabine: 1000 mg/m(2) d 1,8 carboplatin: AUC=5 d 1 q 21d x 2 followed by paclitaxel 80 mg/m(2) q wk x 6 followed by a 2 week break and then repeated until progression. 47 patients were entered. Stage IIIb/IV: 8/39, PS 2/3=26/19, HIV infection=2, solid organ transplantation=2. 12 (25%) had brain metastases. Thirty-nine patients completed two cycles of carboplatin/gemcitabine and 29 pts received at least one cycle of paclitaxel. Overall response rate was 19% (95% CI 1.2-31.7%). Median event free, overall and 1-year survivals were 3.3 months, 5.8 months and 8.4%. Toxicity was moderate with 19% experiencing grade 4 neutropenia (11% with febrile neutropenia). Sequential carboplatin/gem...Continue Reading

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Citations

Apr 3, 2009·Current Opinion in HIV and AIDS·Liron Pantanowitz, Bruce J Dezube
Sep 27, 2012·International Journal of Clinical Oncology·Patricia M M B SoetekouwVivianne C G Tjan-Heijnen
Apr 20, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jean-François MorèreDenis Moro-Sibilot
Apr 11, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C Krisl, V P Doan
Feb 11, 2015·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Prinessa Chellan, Peter J Sadler
Nov 20, 2016·Transplantation·Jacques Dantal, Mario Campone

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