Phase II trial of imatinib maintenance therapy after irinotecan and cisplatin in patients with c-Kit-positive, extensive-stage small-cell lung cancer

Clinical Lung Cancer
Bryan J SchneiderShirish M Gadgeel

Abstract

The prognosis for patients with extensive-stage small-cell lung cancer remains poor. This trial was designed to evaluate irinotecan/cisplatin plus maintenance imatinib in patients with c-Kit-positive disease (the transmembrane receptor c-Kit is the product of the c-KIT protooncogene). Immunohistochemistry for c-Kit was performed before enrollment. Treatment consisted of irinotecan 65 mg/m2 on days 1 and 8 plus cisplatin 60 mg/m2 on day 1 and every 21 days for 4 cycles. Imatinib was administered at 400 mg twice a day until progression or unacceptable toxicity occurred. Fourteen patients were enrolled. Slow accrual led to early study termination. Six patients did not begin treatment with imatinib because of disease progression, persistent toxicity, or referral for radiation therapy. Eight patients had a partial response with irinotecan/cisplatin and received imatinib. The median number of weeks on imatinib was 6.1 (range, 4.1-25.1 weeks). Reasons for imatinib discontinuation included disease progression (n = 7) and persistent neutropenia (n = 1). No objective responses to imatinib were evident, but 3 patients (21%) exhibited stable disease for 12, 15, and 25 weeks. The median progression-free survival was 4.3 months (95% CI, 2.9-...Continue Reading

References

Mar 1, 1989·Controlled Clinical Trials·R Simon
Apr 5, 2001·The New England Journal of Medicine·B J DrukerC L Sawyers
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Jan 17, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Allan T van OosteromUNKNOWN European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Mar 26, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H BurgerK Nooter
Dec 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C HeinrichJonathan A Fletcher
May 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicholas C WolffRobert L Ilaria
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laura BoldriniGabriella Fontanini
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elena TamboriniSilvana Pilotti
Sep 7, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·David R SpigelUNKNOWN Minnie Pearl Cancer Research Network

❮ Previous
Next ❯

Citations

Sep 27, 2014·Expert Opinion on Pharmacotherapy·Gregory P Kalemkerian
Mar 15, 2011·Expert Opinion on Investigational Drugs·Leora HornDavid H Johnson
Apr 23, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Bryan J SchneiderGregory P Kalemkerian
Feb 2, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Paul A BunnFred R Hirsch
Apr 10, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Adam SharpTimothy A Yap
Apr 1, 2015·Cancer Treatment Reviews·Steven L WoodAnthony D Whetton
Feb 12, 2015·Japanese Journal of Clinical Oncology·Shigeki UmemuraKoichi Goto
Jan 4, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan YanJiafu Ji
Jan 1, 2013·Lung Cancer Management·Matthew Whitehurst, Alberto Chiappori
Jun 29, 2012·Oncology Letters·Cunjian YiXiangqiong Liu
Aug 11, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomohiro MiyoshiKatsuya Tsuchihara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.