Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Nancy U LinEric P Winer

Abstract

One third of women with advanced human epidermal growth factor receptor 2 (HER-2)-positive breast cancer develop brain metastases; a subset progress in the CNS despite standard approaches. Medical therapies for refractory brain metastases are neither well-studied nor established. We evaluated the safety and efficacy of lapatinib, an oral inhibitor of epidermal growth factor receptor (EGFR) and HER-2, in patients with HER-2-positive brain metastases. Patients had HER-2-positive breast cancer, progressive brain metastases, prior trastuzumab treatment, and at least one measurable metastatic brain lesion. Patients received lapatinib 750 mg orally twice a day. Tumor response was assessed by magnetic resonance imaging every 8 weeks. The primary end point was objective response (complete response [CR] plus partial response [PR]) in the CNS by Response Evaluation Criteria in Solid Tumors (RECIST). Secondary end points included objective response in non-CNS sites, time to progression, overall survival, and toxicity. Thirty-nine patients were enrolled. All patients had developed brain metastases while receiving trastuzumab; 37 had progressed after prior radiation. One patient achieved a PR in the brain by RECIST (objective response rate ...Continue Reading

References

Apr 1, 1988·American Journal of Clinical Oncology·D J StewartK Howard
Jun 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B C Pestalozzi, S Brignoli
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L VogelMichael Press
Jan 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lijo SimpsonAgnes Piotrowski
Jun 19, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G L CeresoliE Villa
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy U LinEric P Winer
Oct 21, 2005·The New England Journal of Medicine·Edward H RomondNorman Wolmark
Mar 28, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M E TrudeauE Eisenhauer
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David M JackmanBruce E Johnson
Dec 29, 2006·The New England Journal of Medicine·Charles E GeyerDavid Cameron
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nancy U Lin, Eric P Winer

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Citations

Jul 16, 2010·International Journal of Clinical Oncology·Hirofumi Mukai
Feb 18, 2011·International Journal of Clinical Oncology·Hideya OnishiMitsuo Katano
Mar 1, 2012·Breast Cancer Research and Treatment·Yi Ling TeoAlexandre Chan
Oct 21, 2011·Pharmaceutical Research·Kunal S TaskarQuentin R Smith
Aug 3, 2013·Current Treatment Options in Oncology·Jaclyn J Renfrow, Glenn J Lesser
Nov 19, 2010·Current Oncology Reports·Eudocia C Quant, Patrick Y Wen
Oct 19, 2011·Current Oncology Reports·Van A Trinh, Wen-Jen Hwu
Apr 15, 2009·Advances in Therapy·Heather McArthur
Jan 9, 2010·Advances in Therapy·J M Bravo Marques
Apr 3, 2013·European Journal of Pharmacology·Silvia Hofer, Bernhard C Pestalozzi
Jan 2, 2013·The Lancet Oncology·Carsten Nieder
Apr 14, 2011·Nature Reviews. Clinical Oncology·April F EichlerRakesh K Jain
Oct 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·David P KodackRakesh K Jain
Jul 18, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S BeslijaUNKNOWN Central European Cooperative Oncology Group (CECOG)
Sep 1, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T Pieńkowski, C C Zielinski
Oct 21, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A NiwińskaK Pogoda
Aug 21, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G MetroS Gori
Sep 10, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E de AzambujaA Awada
Sep 28, 2010·British Medical Bulletin·Laura Tookman, Rebecca Roylance
Apr 13, 2010·Japanese Journal of Clinical Oncology·Hirofumi Mukai
Jun 15, 2010·Japanese Journal of Clinical Oncology·Charles VogelHanlim Moon
Jun 1, 2010·Neuro-oncology·Sylwia AmmounMatthias A Karajannis
Jan 10, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Matthew L BushAbraham Jacob
Aug 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maryam FouladiRichard J Gilbertson
Aug 2, 2011·Journal of Neurosurgery·Brendan FongIsaac Yang
Jun 3, 2011·World Journal of Gastroenterology : WJG·Stavros PeroukidesHaralabos Kalofonos
Feb 5, 2011·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Katerina BouchalovaMarian Hajduch
Apr 8, 2015·Neuro-oncology·Shannon PuhallaEdward Neuwelt

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