Phase II trial of postoperative adjuvant intraperitoneal cisplatin and fluorouracil and systemic fluorouracil chemotherapy in patients with resected gastric cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
O T AtiqM F Brennan

Abstract

This study was performed to assess the short- and long-term toxicities and the impact on relapse pattern and survival of postoperative intraperitoneal (IP) cisplatin and fluorouracil (FU) plus systemic intravenous (IV) FU as adjuvant therapy for gastric cancer patients who are at high risk for recurrence after potentially curative resection (T2N1-2M0 or T3-4N(any)M0). Starting 14 to 28 days after potentially curative resection of primary gastric cancers, 35 patients were given IP cisplatin 25 mg/m2 and FU 750 mg daily for 4 days; FU 750 mg/m2 was concurrently given as a continuous 24-hour i.v. infusion. Five cycles of therapy delivered at 1-month intervals were used. After a median follow-up of 24 months, 51% of patients remain alive and free of disease. Sixteen patients have recurred; 13 of 16 had an intraabdominal component, whereas three had extraabdominal failure only. Two major treatment-related toxicities were noted: neutropenia and a late toxicity of peritoneal fibrosis (sclerosing encapsulating peritonitis [SEP]). There was one postoperative death. Eleven patients underwent second laparotomy: five patients had SEP, two patients had bowel obstruction from adhesions unrelated to SEP, and four patients had recurrent cancer...Continue Reading

Citations

Jul 1, 1995·Annals of Surgical Oncology·M F Brennan
May 30, 2003·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·John S Macdonald
Jun 1, 1996·The British Journal of Surgery·A M Averbach, P Jacquet
Aug 20, 2002·Arquivos De Gastroenterologia·Sandra MandorwskiNora Manoukian Forones
Apr 18, 2003·The European Journal of Surgery = Acta Chirurgica·Karl-Gunnar JanungerBengt Glimelius
Sep 3, 2018·ANZ Journal of Surgery·Clodagh ManganTitus Augustine
Dec 12, 2018·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Manphool SinghalAdnan M Sheikh
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