Phase II trial on neoadjuvant intravenous and trans-uterine arterial chemotherapy for locally advanced bulky cervical adenocarcinoma

Gynecologic Oncology
Hiroshi TsubamotoShozo Hirota

Abstract

A phase II trial on neoadjuvant trans-uterine arterial chemotherapy (TUAC) followed by type III radical hysterectomy (RH) was conducted for patients with bulky cervical adenocarcinoma (AC). Tumors of >4 cm were eligible. The neoadjuvant regimen comprised paclitaxel (60 mg/m(2) intravenously on days 1, 8, and 15) and cisplatin (70 mg/m(2) TUAC followed by transcatheter embolization with gelatin sponge particles on day 2) repeated every 3 weeks for 3 cycles. The primary endpoints were clinical and pathological responses. Twenty-two patients (median age, 51 years; range, 33-75 years) were enrolled. The International Federation of Gynecology and Obstetrics stages were IB2 (9 patients), IIA-IIB (8), IIIB (3), and IVA (2). The adeno/adenosquamous ratio was 16/6. The overall clinical response rate was 95.4% (95% confidence interval [CI], 86.7-100%). RH was completed in 19 patients (86%), including 2 stage IVA patients who underwent anterior or posterior pelvic exenteration. Of the 19 patients, no residual malignant cells were found pathologically in 4; thus, the pathological complete response rate was 18% (4/22). No patients experienced grade 4 thrombocytopenia or febrile neutropenia or required platelet transfusions. The 5-year progr...Continue Reading

References

Jun 1, 1991·Obstetrics and Gynecology·M P Hopkins, G W Morley
Nov 1, 1989·Gynecologic Oncology·W KleineA Pfleiderer
Sep 1, 1988·Gynecologic Oncology·L C KilgoreE E Partridge
Mar 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U KlaassenS Seeber
Oct 4, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T IrieN Terakawa
Dec 26, 2001·Gynecologic Oncology·Jayanthi S LeaJohn O Schorge
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierluigi Benedetti-PaniciFabio Landoni
May 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maurie MarkmanMark Baker
Mar 22, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V HessM E Gore
Jan 31, 2004·Gynecologic Oncology·A BaalbergenTh J M Helmerhorst
May 28, 2004·International Journal of Clinical Oncology·Tsutomu TabataNagayasu Toyoda
Jul 2, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T SaitoR Kudo
Sep 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Freddie BrayElisabete Weiderpass
Mar 15, 2006·Cancer Chemotherapy and Pharmacology·Taisuke MoriHideo Honjo
May 13, 2006·Gynecologic Oncology·Hermann HertelUNKNOWN German Association of Gynecologic Oncologists (AGO)
Aug 4, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K Bm LeeS Y Ha
Aug 8, 2006·Gynecologic Oncology·Simone MarnitzAchim Schneider
Oct 2, 2007·Gynecologic Oncology·Michael P Hopkins, William Schnettler
Dec 13, 2007·Gynecologic Oncology·Juan E Sardi
Mar 1, 2008·International Journal of Clinical Oncology·Howard D HomesleyAl A Elbendary
Apr 19, 2008·The New England Journal of Medicine·Joseph A SparanoNancy E Davidson
Jul 22, 2008·The New England Journal of Medicine·Sercan AksoyKadri Altundag
Sep 9, 2008·Gynecologic Oncology·Laszlo UngarZoltan Novak
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bradley J MonkDavid Cella
Nov 3, 2009·Gynecologic Oncology·Lilian T GienGillian Thomas
Jun 15, 2010·International Journal of Radiation Oncology, Biology, Physics·Yi-Ting HuangJi-Hong Hong

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Citations

Dec 29, 2013·Gynecologic Oncology Case Reports·Hiroshi TsubamotoRiichiro Kanazawa
Jun 25, 2016·Journal of Vascular and Interventional Radiology : JVIR·De-Hua WuQiang Shu
Jul 19, 2018·Current Medical Research and Opinion·Joanna Jonska-GmyrekBeata Kotowicz
Nov 22, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hiroshi TsubamotoShozo Hirota

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