PMID: 6166363Aug 1, 1981Paper

Phase II trials of Baker's antifol, bleomycin, CCNU, streptozotocin, tilorone, and 5-fluorodeoxyuridine plus arabinosyl cytosine in metastatic breast cancer

Cancer
F J CummingsDouglass C Tormey

Abstract

A total of 202 patients with advanced breast cancer were entered into two prospectively randomized Phase II trials conducted by the Eastern Cooperative Oncology Group, in an effort to identify promising agents and combinations for previously treated cases. Patients in Study 1 received bleomycin, CCNU, or streptozotocin and those in Study 2 received tilorone, Baker's antifol, or a combination of 5-fluorodeoxyuridine plus arabinosyl cytosine. Partial responses were seen only with bleomycin, Baker's antifol, and 5-fluorodeoxyuridine plus arabinosyl cytosine. The median times to treatment failure ranged from 3.6 weeks to 5.7 weeks, and the median survival times, from 8 weeks to 25 weeks for tilorone and bleomycin, respectively. Toxic reactions was primarily hematologic and gastrointestinal, but skin, neurologic, respiratory, and renal abnormalities were noted in some treatment arms. The treatment schedules outlined and the toxic effects noted provide background information that might prove useful in designing complex new chemotherapeutic programs, since there is pharmacological rationale for incorporating some of the agents tested into present standard combination chemotherapy regimens.

References

Jan 1, 1980·American Journal of Ophthalmology·J N WeissW Regelson

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Citations

Sep 1, 1992·Teratology·R D TerryH E Renis
Dec 11, 2008·Journal of the National Cancer Institute·Davide MauriJohn P A Ioannidis
Apr 1, 1995·American Journal of Reproductive Immunology : AJRI·T A Marks, D E Tracy
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J KajantiA G Maiche
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·P M CzaykowskiA Oza
Apr 17, 2016·Trends in Pharmacological Sciences·Sahdeo PrasadBharat B Aggarwal

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