PMID: 11903179Mar 21, 2002Paper

Phase III, randomized, double-blind, cross-over comparison of gadoteridol and gadopentetate dimeglumine in magnetic resonance imaging of patients with intracranial lesions

Australasian Radiology
A GrecoM T McNamara

Abstract

This study compares the efficacy and safety of gadoteridol with that of gadopentetate dimeglumine for enhanced MRI in subjects with intracranial lesions. A total of 92 subjects at three European centres underwent one MRI study enhanced with 0.1 mmol/kg gadoteridol and another with 0.1 mmol/kg gadopentetate dimeglumine. Contrast agents were assigned in random order, separated by 3-7 days. Eighty subjects were evaluated for efficacy. The presence of pathology, degree of enhancement, location and number of lesions, as well as additional information gained, were compared for each subject's unenhanced and enhanced scans for both the gadoteridol and gadopentetate dimeglumine examination. Safety was evaluated in all treated subjects by means of pre- and post-dose vital signs, laboratory tests and by monitoring for adverse events. There was no significant difference in the number of lesions visualized pre- and post-contrast for the two contrast agents. A high degree of correlation was noted between the two blinded readers. When post-contrast image sets were compared between contrast agents, there was no significant difference in superiority of one agent over the other for any of the evaluators (P > 0.05). No significant differences for...Continue Reading

References

Dec 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H P NiendorfW Clauss
Jan 1, 1990·Radiology·H A GoldsteinD M Blumenfield
Jan 1, 1995·Journal of Magnetic Resonance Imaging : JMRI·A Y OlukotunT R Lucas
Sep 1, 1994·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·M J KuhnT J Gleason
Nov 15, 1995·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·D E HieronimD P Swanson
Jan 1, 1997·European Radiology·V M Runge, J R Parker
Oct 3, 1999·Journal of Magnetic Resonance Imaging : JMRI·F G Shellock, E Kanal

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Citations

Mar 16, 2004·European Radiology·M Essig
Nov 20, 2003·Topics in Magnetic Resonance Imaging : TMRI·Miles A Kirchin, Val M Runge
Sep 23, 2008·AJR. American Journal of Roentgenology·Patrick M Colletti
Mar 24, 2009·AJR. American Journal of Roentgenology·Val M Runge
Sep 26, 2013·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Giovanni MoranaAlberto Dorigo
Dec 22, 2015·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Akio TanakaJosy Breuer
Mar 29, 2008·European Journal of Radiology·Aart J van der Molen, Marie-France Bellin
May 24, 2014·AJNR. American Journal of Neuroradiology·E KanalH A Rowley
Oct 1, 2010·The Neuroradiology Journal·M Essig, L Gerigk
Jul 12, 2017·The Neuroradiology Journal·Rupa RadhakrishnanHumberto Morales

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