PMID: 9416409Jan 7, 1998Paper

Phase III randomized trial of surgery with or without intraoperative photodynamic therapy and postoperative immunochemotherapy for malignant pleural mesothelioma

Annals of Surgical Oncology
H I PassS M Steinberg

Abstract

Patients with malignant pleural mesothelioma (MPM) usually die of progressive local disease. This report describes the results of a Phase III trial comparing maximum debulking surgery and postoperative cisplatin, interferon alpha-2b, and tamoxifen (CIT) immunochemotherapy with and without intraoperative photodynamic therapy (PDT) to determine (1) whether such a multimodal approach can be performed with minimum morbidity and mortality in malignant pleural mesothelioma (MPM), and (2) whether first-generation (i.e., 630-nm laser light, Photofrin II) intrapleural PDT impacts on local recurrence of survival. From July 1993 to June 1996, 63 patients with localized MPM were randomized to either PDT or no PDT. The tumors of 15 patients could not be debulked to 5 mm. Patients assigned to PDT (n = 25) and no PDT (n = 23) were similar with respect to age, sex, tumor volume, and histology. The type of resection (11 pleurectomies and 14 pneumonectomies vs. 12 pleurectomies and 11 pneumonectomies), length postoperative stay, and ICU time were comparable (PDT vs. no PDT). There was one operative death (hemorrhage), and each group had two bronchopleural fistulas. Postoperative staging divided patients into the following categories: stage I: PD...Continue Reading

References

Mar 1, 1984·International Journal of Radiation Oncology, Biology, Physics·B S HilarisN Martini
Jan 1, 1994·Annals of Surgical Oncology·H I PassJ W Cole
Jun 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V RuschD Kelsen
Oct 1, 1993·Current Problems in Surgery·H I Pass, H W Pogrebniak
Jun 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D J SugarbakerK H Antman
Apr 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·V W Rusch, E Venkatraman

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Citations

Jun 5, 2002·Current Oncology Reports·Lambros Zellos, David J Sugarbaker
Jun 12, 2002·Current Treatment Options in Oncology·H L Kindler
Jan 8, 2003·Lasers in Surgery and Medicine·Thorsten KruegerHans-Beat Ris
May 18, 2005·Technology in Cancer Research & Treatment·Z Huang
Jun 11, 2005·Current Oncology Reports·Ranjit Kumar Goudar
Oct 26, 2005·Lasers in Surgery and Medicine·Thorsten KruegerHans-Beat Ris
Sep 2, 2008·Current Treatment Options in Oncology·Michael KentRaja Flores
Jun 9, 2010·Expert Review of Respiratory Medicine·David J Sugarbaker, Andrea S Wolf
Aug 27, 2015·Expert Review of Respiratory Medicine·Angela BononiMichele Carbone
Dec 3, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Anna C BibbyIoannis Psallidas
Jun 4, 2019·Photodermatology, Photoimmunology & Photomedicine·Rebecca L YanovskySteven T Chen
Jul 24, 2020·Nature Reviews. Clinical Oncology·Xingshu LiXiaoyuan Chen
Jul 17, 1999·Current Opinion in Pulmonary Medicine·P Astoul
Jun 5, 2002·Current Oncology Reports·W Roy Smythe
Dec 18, 2001·Journal of Surgical Oncology·N MerrittJ D Urschel
Jun 16, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Daniel H Sterman, Steven M Albelda
Jun 4, 2008·Current Opinion in Pulmonary Medicine·Michael D ZervosHarvey I Pass
Jan 23, 2009·Clinical Orthopaedics and Related Research·S BurchS K Bisland
Jul 27, 2000·Current Opinion in Pulmonary Medicine·Y C LeeA W Musk
Jun 21, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Isabelle OpitzHans-Beat Ris
Feb 2, 2011·Journal of the Royal Society of Medicine·Elaine TehTom Treasure
Jan 7, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Victor H GerbaudoDavid J Sugarbaker
Feb 6, 2015·Tuberculosis and Respiratory Diseases·Jae-Wook Ryu, Youn Seup Kim
Apr 9, 2004·International Journal of Occupational and Environmental Health·Duncan J StewartKenneth J O'Byrne
Jun 12, 2002·Current Treatment Options in Oncology·S M HahnJ Friedberg
Aug 4, 2007·The Oncologist·Giovanni Luca CeresoliArmando Santoro
Feb 26, 2011·Expert Review of Respiratory Medicine·Joseph S Friedberg
May 26, 2017·Lasers in Surgery and Medicine·Sabrina CavinJean Y Perentes
Jan 26, 2016·International Journal of Molecular Sciences·Biniam KidaneKazuhiro Yasufuku
Mar 17, 2016·Oncotarget·Tadanobu NagayaHisataka Kobayashi
Mar 31, 2000·Current Opinion in Pulmonary Medicine·A M Boylan
Jan 7, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Lonny YarmusDavid Feller-Kopman
May 28, 2011·CA: a Cancer Journal for Clinicians·Patrizia AgostinisJakub Golab
May 23, 2015·Frontiers of Physics·Timothy C ZhuKeith A Cengel
Jan 19, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hedy L KindlerRaffit Hassan
Jan 9, 2018·The Cochrane Database of Systematic Reviews·Omar Abdel-RahmanMostafa Eltobgy
Jun 8, 2017·Molecular Cancer Research : MCR·Tadanobu NagayaHisataka Kobayashi

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