PMID: 11148562Jan 10, 2001Paper

Phase I/II study of intravenous nedaplatin and intraarterial cisplatin with transcatheter arterial embolization for patients with locally advanced uterine cervical carcinoma

Cancer
S AdachiN Nakao

Abstract

Nedaplatin, a platinum analog with less renal toxicity and similar efficacy for cervical carcinoma, recently has been shown to have a synergistic effect on cervical carcinoma lines in combination with cisplatin. To determine the clinical efficacy of this combination in patients with cervical carcinoma, the authors conducted a Phase I/II study of intravenous nedaplatin and intraarterial cisplatin combined with transcatheter arterial embolization (TAE). Eligibility criteria were as follows: cervical carcinoma (Stages IB2-IV; International Federation of Gynecology and Obstetrics), 16-70 years of age, performance status between 0 and 2, and adequate bone marrow, renal, and hepatic function. Nedaplatin (40-70 mg/m2) was administered intravenously on Day 1 followed by intraarterial administration of cisplatin (70 mg/m2) on Day 3 via both uterine arteries by using the Seldinger method. This then was followed by TAE. This course of treatment was repeated every 3 weeks for 3 cycles. Patient data were as follows: age 37-68 (median, 55 years) and Stages IB2:4, IIA:3, IIB:2, IIIA:1, IIIB:3, IVA:2 carcinoma. The response to therapy was defined by magnetic resonance imaging as follows: partial response in 60% (9 of 15) of patients, complete ...Continue Reading

References

Jan 1, 1991·Gynecologic Oncology·P R DottinoC J Cohen
Dec 1, 1994·Gynecologic Oncology·F GirardiH Pickel
Feb 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P SculierR Sergysels
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Citations

Jan 3, 2003·Oral Oncology·Masamichi ItaYoshikazu Hayatsu
Jun 12, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hiroshi TsubamotoShozo Hirota
Nov 22, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hiroshi TsubamotoShozo Hirota
Feb 1, 2013·International Journal of Pediatrics·Irene Alba-AlejandreOrsolya Genzel-Boroviczény
Apr 9, 2016·Cancer Investigation·Hui PangLi Cai
Nov 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Xiang-Yu SuFang-Fang Shi
Dec 29, 2013·Gynecologic Oncology Case Reports·Hiroshi TsubamotoRiichiro Kanazawa
Jun 25, 2016·Journal of Vascular and Interventional Radiology : JVIR·De-Hua WuQiang Shu
Sep 24, 2014·Surgical Oncology Clinics of North America·Bruno C Odisio, Michael J Wallace
Apr 18, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ping LiZhenming Fu

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