PMID: 8960515Nov 1, 1996Paper

Phase I/II study of proton beam irradiation for the treatment of subfoveal choroidal neovascularization in age-related macular degeneration: treatment techniques and preliminary results

International Journal of Radiation Oncology, Biology, Physics
L T YonemotoJ M Slater

Abstract

Age-related macular degeneration is the prevalent etiology of subfoveal choroidal neovascularization (CNV). The only effective treatment is laser photocoagulation, which is associated with decreased visual acuity following treatment in most patients. This study assessed both the response of subfoveal CNV to proton beam irradiation and treatment-related morbidity. We evaluated preliminary results in patients treated with an initial dose of 8 Cobalt Gray Equivalents (CGE) using a relative biological effectiveness (RBE) of 1.1. Twenty-one patients with subfoveal CNV received proton irradiation to the central macula with a single fraction of 8 CGE; 19 were eligible for evaluation. Treatment-related morbidity was based on Radiation Therapy Oncology Group (RTOG) criteria; response was evaluated by Macular Photocoagulation Study (MPS) guidelines. Fluorescein angiography was performed; visual acuity, contrast sensitivity, and reading speed were measured at study entry and at 3-month intervals after treatment. Follow-up ranged from 6 to 15 months. No measurable treatment-related morbidity was seen during or after treatment. Of 19 patients evaluated at 6 months, fluorescein angiography demonstrated treatment response in 10 (53%); 14 (74%...Continue Reading

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Citations

Nov 18, 2000·American Journal of Ophthalmology·H Kobayashi, K Kobayashi
May 20, 1999·American Journal of Ophthalmology·D H CharS Kroll
Oct 31, 1998·Harvard Women's Health Watch
Dec 22, 1999·Ophthalmology·R F SpaideJ A Sorenson
Nov 10, 2000·International Journal of Radiation Oncology, Biology, Physics·J O ArchambeauJ M Slater
Apr 8, 1998·International Journal of Radiation Oncology, Biology, Physics·M AkmansuM Or
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·V Vinh-HungG Storme
Jun 30, 2000·The British Journal of Ophthalmology·H Kobayashi, K Kobayashi
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May 14, 2014·The British Journal of Ophthalmology·Ling ChenJoan W Miller
May 19, 2000·The British Journal of Radiology·U Chakravarthy, G MacKenzie
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Jun 30, 2000·Clinical Eye and Vision Care·T J Stokkermans
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Mar 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniela Schulz-Ertner, Hirohiko Tsujii
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Jan 27, 1998·Ophthalmology·R F SpaideD Abramson

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