PMID: 2115817Jan 1, 1990Paper

Phase I/II study of recombinant interferon alpha and gamma in advanced progressive renal-cell carcinoma

Cancer Immunology, Immunotherapy : CII
P H De MulderO Damsma

Abstract

In vitro studies have documented the synergistic antiviral and antiproliferative activity of recombinant interferon alpha (rIFN alpha) and rIFN gamma. Furthermore, rIFN gamma is a strong immunomodulator with optimal effects at a relative low dose (0.1 mg/m2). On the basis of these observations, we began a phase I/II study with the combination of rIFN gamma at 100 micrograms/m2 (2 x 10(6) IU/m2) and rIFN alpha 2c 6 micrograms/m2 (2 x 10(6) IU/m2), injected twice a week subcutaneously. In cases of stable or progressive disease we increased the dose of rIFN alpha 2c every 2 weeks by 6 micrograms/m2 until the maximum tolerated dose was reached. A total of 32 patients with proven progressive renal-cell carcinoma were included. Of the 31 eligible patients, 21 were male and 10 female, their average age was 57.2 years (range 35-72), 28 had had nephrectomy, their median Karnofsky performance status was 90% (70%-100%), and their tumors were localized predominantly to visceral tissue. In 2, response was complete and in 6 it was partial, for a response rate of 25%. The disease had stabilized in 5 patients and progressed in 16. The median duration of partial response was 14 months (8-16 months); of 2 cases of complete response, 1 persists (...Continue Reading

References

Aug 1, 1978·The Journal of Urology·J B DekernionR B Smith
Feb 1, 1988·The Journal of Urology·M B GarnickS A Rudnick
Mar 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A E MaluishR G Steis
Jan 1, 1988·Seminars in Surgical Oncology·A D GeboersO Damsma
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B Y Rubin, S L Gupta
Apr 1, 1980·Cancer·Jean B DeKERNION, David Berry

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