Phase III study of two different dosing schedules of erythropoietin in anemic patients with cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
David P SteensmaCharles L Loprinzi

Abstract

To compare maintenance epoetin alfa administered once every 3 weeks with continued weekly epoetin alfa for patients with cancer-associated anemia. Eligible patients were randomly assigned at enrollment to receive three weekly doses of epoetin alfa 40,000 U subcutaneously (SC), followed by either standard weekly epoetin alfa (40K arm) or 120,000 U of epoetin alfa (120K arm) SC every 3 weeks for 18 additional weeks. Three hundred sixty-five patients were enrolled. One hundred eighty-three patients were assigned to the 40K arm, and 182 were assigned to the 120K arm. There was no difference in the proportion of patients requiring transfusions during the study (23% in 40K arm and 18% in 120K arm, P = .22) or specifically during the maintenance phase (13% in 40K arm v 15% in 120K arm, P = .58). Patients randomly assigned to the 40K arm were more likely to have a > or = 2 or > or = 3 g/dL hemoglobin (Hb) increment, were more likely to have a drug dose held because of high Hb, and had higher mean end-of-study Hb levels. Toxicities, including thromboembolism, and overall survival were similar. Patients in the 40K arm had a higher global quality of life (QOL) at baseline for unclear reasons, whereas patients in the 120K arm had a greater...Continue Reading

References

Oct 1, 1978·Cancer Nursing·R McCorkle, K Young
Jun 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W OsterR Mertelsmann
Jun 14, 1990·The New England Journal of Medicine·H LudwigU Barnas
Jun 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·D L Fairclough, D F Cella
Jul 14, 1999·Psychosomatics·M BretscherC Loprinzi
Jun 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T J LittlewoodUNKNOWN Epoetin Alfa Study Group
Jun 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J L GabriloveL H Einhorn
Jun 8, 2001·Seminars in Oncology·H Ludwig, K Strasser
Oct 18, 2001·Current Opinion in Hematology·L T Goodnough
Aug 22, 2002·Journal of the National Cancer Institute·Johan VansteenkisteUNKNOWN Aranesp 980297 Study Group
Feb 5, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D L PatrickUNKNOWN Epoetin Alfa Study Group
Aug 7, 2003·The Lancet Oncology·Brian Leyland-Jones, UNKNOWN BEST Investigators and Study Group
Sep 6, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D KotasekUNKNOWN Aranesp 980291 Study Group
Jan 16, 2004·Lancet·Brian Leyland-Jones, Salaheddin Mahmud
Jan 16, 2004·Lancet·Neil Blumberg, Joanna M Heal
May 26, 2004·Journal of Pain and Symptom Management·Margaret Q RosenzweigAdam M Brufsky
May 27, 2004·Current Oncology Reports·David P Steensma
Jun 15, 2004·Statistics in Medicine·Steven A Julious
Sep 29, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E WitzigRoscoe F Morton
Oct 16, 2004·Oncology·John Glaspy, Juergen Dunst
Aug 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David P Steensma, Charles L Loprinzi
Sep 26, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vasilios G AthyrosMoses Elisaf

❮ Previous
Next ❯

Citations

Jun 2, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Vernon P MontoyaFrancois E Wilhelm
Nov 19, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·François LüthiChristian Monnerat
Oct 1, 2008·Clinical and Experimental Medicine·Fabrizio FranchiPatrizia Seminara
Nov 3, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A Pelegrí
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M DicatoM Diederich
Oct 6, 2007·World Journal of Surgery·Keishi YamashitaMasahiko Watanabe
Aug 19, 2006·Expert Opinion on Investigational Drugs·Jennifer A Ziegler, Jon D Herrington
Jul 18, 2008·Supportive Cancer Therapy·David H Henry
Dec 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C BokemeyerUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC) Taskforce for the Elderly
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Benny Chung-Ying Zee
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David P Steensma, Charles L Loprinzi
Mar 14, 2008·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Stacy S ShordSandra Cuellar
Jul 9, 2010·The Cochrane Database of Systematic Reviews·Ollie MintonPatrick Stone
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Thomy ToniaJulia Bohlius
Dec 7, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Raymond J Muller, David Baribeault
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Julia BohliusAndreas Engert
Feb 29, 2008·The Oncologist·Ananth Gouri Shankar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.