Phase III Trial of an emulsion containing trolamine for the prevention of radiation dermatitis in patients with advanced squamous cell carcinoma of the head and neck: results of Radiation Therapy Oncology Group Trial 99-13

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Elizabeth A ElliottRadiation Therapy Oncology Group Trial 99-13

Abstract

This multicentered phase III trial was designed to compare an emulsion containing trolamine against the usual supportive care within each participating institution for patients with head and neck cancer undergoing radiation therapy. Patients with biopsy-proven squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx were randomly assigned to one of the following treatments: prophylactic trolamine emulsion, interventional trolamine emulsion, or declared institutional preference. The primary outcome was the reduction in grade 2 or higher skin toxicity, as per National Cancer Institute Common Toxicity Criteria version 2.0. Secondary outcomes included patient-reported quality of life (QOL). From October 2000 to April 2002, 547 patients from 51 institutions were entered onto the trial. The average age was 59 years. Patients were predominately male (79%) and most continued to use tobacco products (52%). The rates of grade 2 or higher radiation dermatitis were 79%, 77%, and 79% in the prophylactic, interventional, and institutional preference arms of the study, respectively. No significant differences in QOL were found. The results of this trial demonstrate no advantage for the use of trolamine in reducing the in...Continue Reading

References

Jan 1, 1991·Acta Oncologica·A G MaicheH Mäki-Hokkonen
Jun 1, 1982·Radiology·M E PoteraJ A Stryker
Jan 1, 1981·Journal of Chronic Diseases·W O SpitzerB R Catchlove
May 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G P BrowmanA Girard
Sep 1, 1996·International Journal of Radiation Oncology, Biology, Physics·M S WilliamsW D Eggleston
Feb 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·V LiguoriJ Bernier
Jan 1, 1997·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·B CoulombL Dubertret
Apr 12, 2000·International Journal of Radiation Oncology, Biology, Physics·A TrottiW Curran
Mar 16, 2004·Oncology Nursing Forum·Mihkaila Maurine Wickline
Apr 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P PommierX Montbarbon
Sep 24, 2004·Oncology Nursing Forum·Timothy Kost, UNKNOWN Medix Pharmaceuticals Americas, Inc

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Citations

Feb 23, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Hamza Abbas, René-Jean Bensadoun
Jun 2, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mario E LacoutureUNKNOWN MASCC Skin Toxicity Study Group
Oct 16, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yuejiao ZhangXiaoling Shao
Aug 15, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rebecca K S WongMario E Lacouture
Dec 7, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M J Palayekar, T J Herzog
Apr 25, 2014·Advances in Wound Care·Sadanori Akita
Jul 24, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A ModestoY Pointreau
Jul 23, 2011·Journal of the American Academy of Dermatology·Yevgeniy BalagulaMario E Lacouture
Apr 30, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S BenomarB K El Gueddari
Jun 16, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C ChargariY M Kirova
Sep 4, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Louis BazireYoulia M Kirova
Jan 6, 2012·The Journal of Investigative Dermatology·Julie L Ryan
Nov 4, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christian GiroWilfried Budach
Jan 25, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jolie RingashJohn Waldron
Dec 1, 2007·Veterinary and Comparative Oncology·A K Flynn, D M Lurie
Jul 6, 2010·Journal of Medical Imaging and Radiation Oncology·S KumarJ Shafiq
Mar 30, 2016·American Journal of Clinical Dermatology·Manni SinghSadanori Akita
Sep 8, 2015·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·I FromantinM Le Mée
Feb 4, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Patries M HerstMarieke L Jasperse
Oct 2, 2012·Clinical Journal of Oncology Nursing·Nancy Dendaas
Sep 29, 2011·Clinical Journal of Oncology Nursing·Deborah FeightMaurene McQuestion
Feb 2, 2010·Clinical Journal of Oncology Nursing·Clara Granda-CameronDavid Mintzer
Jun 3, 2016·Dermatology and Therapy·Fleta N BrayKeyvan Nouri
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jolie Ringash
Mar 1, 2017·International Journal of Radiation Oncology, Biology, Physics·Jolie Ringash
Mar 2, 2017·International Journal of Dermatology·Michelle VillavicencioJudith Domínguez-Cherit
May 21, 2015·Revista da Escola de Enfermagem da U S P·Franciane SchneiderStela Adami Vayego
Dec 21, 2018·International Journal of Radiation Biology·José L SorianoBeatriz Clares
Nov 15, 2006·Annals of Surgical Oncology·Neeltje SteeghsHans Gelderblom

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