Phase I/II trial of hyperfractionated radiation and chemotherapy followed by surgery in stage III lung cancer

The Annals of Thoracic Surgery
Martin J EdelmanM J Krasna

Abstract

We have previously demonstrated that high-dose chemoradiotherapy followed by resection for patients selected on the basis of mediastinal sterilization was feasible and resulted in excellent outcomes. This study was designed to determine the ability to intensify our prior approach utilizing hyperfractionated radiation and more aggressive consolidative chemotherapy. Patients with documented stage IIIA/B nonsmall-cell lung cancer, performance status 0 to 2, and adequate organ function were eligible. A phase I portion utilized escalating doses of carboplatin and vinorelbine, commencing with areas under the curve of 1 and 5 mg/m(2), respectively, and concurrent 69.6 Gy hyperfractionated radiotherapy. A phase II portion utilized the identical radiotherapy with carboplatin/vinorelbine at the maximum tolerated dose established in phase I. Patients for whom mediastinal nodal clearance was demonstrated underwent resection. All patients were to receive consolidation chemotherapy consisting of carboplatin/vinorelbine for three cycles, followed by docetaxel for three cycles. Prophylactic cranial irradiation was offered to patients after completion of therapy. Forty-seven patients participated in the study (33 IIIA, 14 IIIB; 15 men, 32 women...Continue Reading

References

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Citations

Mar 10, 2012·Journal of Cancer Research and Clinical Oncology·Mirko NitscheOlivier Pradier
Sep 22, 2012·Interactive Cardiovascular and Thoracic Surgery·Volker StegerThorsten Walles
Feb 25, 2010·Current Opinion in Oncology·Sofie De CraeneJan P van Meerbeeck
Apr 24, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Matthew KoshyKatherine S Virgo
Sep 4, 2013·The Annals of Thoracic Surgery·Masafumi YamaguchiYukito Ichinose
Aug 13, 2013·Thoracic Surgery Clinics·R Taylor Ripley, Valerie W Rusch
Feb 20, 2013·Revue des maladies respiratoires·P Bonnette
Sep 28, 2015·The Annals of Thoracic Surgery·Stephen R BroderickVarun Puri
Oct 12, 2011·Surgical Oncology Clinics of North America·Benedict D T DalyMark J Krasna
May 31, 2011·The Annals of Thoracic Surgery·Anthony W KimL Penfield Faber
Jul 8, 2010·International Journal of Radiation Oncology, Biology, Physics·Matthew KoshyMohan Suntharalingam
Jul 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Mark J Krasna
Jun 12, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Dipesh UpretyAlex A Adjei
Oct 26, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kevin X LiuLisa Singer

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