PMID: 3759671Jan 1, 1986Paper

Phase-locking in the cochlear nerve of the guinea-pig and its relation to the receptor potential of inner hair-cells

Hearing Research
A R Palmer, I J Russell

Abstract

The high-frequency limit of phase-locking has been measured in fibres of the auditory nerve in the guinea-pig. It is shown that phase-locking begins to decline at about 600 Hz and is no longer detectable above 3.5 kHz which is about 1 octave lower than in the cat, squirrel monkey and some birds. Direct measurements of the cochlear afferent fibre synaptic delay are consistent with indirect estimates from phase-locking, both giving values of 0.7-0.8 ms. Measurements of the receptor potentials of inner hair-cells in the guinea pig cochlea indicate that as the stimulus frequency is increased there is a progressive decrease in the a.c. component compared to the steady depolarization. The cause of this decline is the low-pass filtering of the a.c. component by the hair-cell membrane. The cut-off and slope of the decline in the a.c. component is consistent with the suggestion that this process is the limiting factor in cochlear nerve fibre phase-locking. The implications of these findings for interspecies variation in phase-locking cut-off, for cochlear mechanisms and for the encoding of complex sounds are discussed.

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Citations

Nov 4, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Lutz Wiegrebe, Veronika Sonnleitner
Feb 24, 2007·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Christine Köppl, Otto Gleich
Sep 18, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Yossi YovelHans-Ulrich Schnitzler
Jul 5, 2007·Biological cybernetics·Arjan Boonman, Joachim Ostwald
May 21, 2008·Biological cybernetics·Lutz Wiegrebe
May 24, 2006·Journal of the Association for Research in Otolaryngology : JARO·Enrique A Lopez-Poveda, Almudena Eustaquio-Martín
Dec 19, 2008·Journal of the Association for Research in Otolaryngology : JARO·Alan R Palmer, Trevor M Shackleton
Nov 19, 2009·Journal of the Association for Research in Otolaryngology : JARO·Andrei N Temchin, Mario A Ruggero
Oct 1, 1988·Hearing Research·M GummerB M Johnstone
Aug 1, 1989·Hearing Research·I H Van Stokkum, C C Gielen
Nov 1, 1990·Hearing Research·R C Kidd, T F Weiss
Aug 1, 1992·Hearing Research·D Harvey, K P Steel
Apr 1, 1992·Hearing Research·M A Cheatham, P Dallos
Nov 1, 1994·Hearing Research·R S HeffnerG Koay
Apr 1, 1994·Hearing Research·R KlinkeJ Smolders
Jul 10, 2003·Trends in Neurosciences·David McAlpine, Benedikt Grothe
Aug 25, 2001·Hearing Research·J V FitzGeraldA G Paolini
Nov 5, 1997·Hearing Research·M Chatterjee, J J Zwislocki

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