Phase one pilot study using magnetic resonance spectroscopy to predict the histology of radiofrequency-ablated renal tissue

European Urology
Joshua M SternJeffrey A Cadeddu

Abstract

Recent advances in magnetic resonance (MR) technology have allowed for high-resolution ex vivo spectroscopy on small, intact tissue samples. We examined the capability of (1)H magnetic resonance magic angle spinning (MR-MAS) to correctly characterize post-radiofrequency ablation (RFA) renal biopsies from human samples, compared with standard histology and cross-sectional imaging. A minimum of two, 18G, percutaneous renal biopsies were obtained from ten biopsy-confirmed renal tumors at a mean 26.6 mo (range, 15-48) post-RFA. All patients were considered free of disease by computed tomography criteria. A portion of each sample was immediately frozen at -80 degrees C for spectroscopy and the remainder used for pathological analysis. (1)H MR-MAS was performed blinded with a 14.1-tesla field strength. Prior renal biopsies from nonablated tissue were used as positive controls for the spectral analysis. Concordance between, computed tomography, histology, and MR-MAS was analyzed. All spectroscopy was processed with VNMR software. Histological analysis of all ten post-RFA biopsies demonstrated no cancer or viable tissue. All MR-MAS spectral peaks for each biopsy were consistent with necrosis and, more importantly, indicated an absence ...Continue Reading

References

Feb 13, 2003·Biopolymers·V TugnoliM R Tosi
Apr 13, 2004·The Journal of Urology·J J HwangB J Wood
May 10, 2005·The Journal of Urology·Inderbir S GillAndrew C Novick
May 11, 2005·Urology·Edward D MatsumotoJeffrey A Cadeddu
Sep 6, 2006·The Journal of Urology·Dipen J ParekhS Duke Herrell
Oct 31, 2006·The Journal of Urology·Surena F MatinInderbir S Gill

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