PMID: 8592196Nov 1, 1995Paper

Phase relations of Purkinje cells in the rabbit flocculus during compensatory eye movements

Journal of Neurophysiology
C I De ZeeuwJ I Simpson

Abstract

1. Purkinje cells in the rabbit flocculus that respond best to rotation about the vertical axis (VA) project to flocculus-receiving neurons (FRNs) in the medial vestibular nucleus. During sinusoidal rotation, the phase of FRNs leads that of medial vestibular nucleus neurons not receiving floccular inhibition (non-FRNs). If the FRN phase lead is produced by signals from the flocculus, then the Purkinje cells should functionally lead the FRNs. In the present study we recorded from VA Purkinje cells in the flocculi of awake, pigmented rabbits during compensatory eye movements to determine whether Purkinje cells have the appropriate firing rate phases to explain the phase-leading characteristics of the FRNs. 2. Awake rabbits were sinusoidally rotated about the VA in the light and the dark at 0.05-0.8 Hz with different amplitudes. The phase of the simple spike (SS) modulation in reference to eye and head position was calculated by determining the eye position sensitivity and the eye velocity sensitivity using multivariate linear regression and Fourier analysis. The phase of the SS modulation in reference to head position was compared with the phase of the FRN modulation, which was obtained in prior experiments with the same stimulus...Continue Reading

Citations

Apr 14, 2005·Annals of the New York Academy of Sciences·John S Stahl, Robert A James
Dec 13, 2005·Journal of Neurophysiology·John S StahlChris I De Zeeuw
Feb 1, 2011·The Cerebellum·Laurens WitterFreek E Hoebeek
Dec 10, 2013·Neural Plasticity·Guy CheronJavier Márquez-Ruiz
Apr 28, 2017·Journal of Neurophysiology·Reinoud Maex, Boris Gutkin
Jan 7, 2020·The Journal of Comparative Neurology·Takahiro AndoIzumi Sugihara
Nov 17, 2001·Annals of the New York Academy of Sciences·J C SunC I De Zeeuw
May 6, 2011·Nature Reviews. Neuroscience·Chris I De ZeeuwSebastiaan K Koekkoek
Jun 5, 2013·The European Journal of Neuroscience·Reinoud Maex, Volker Steuber
Feb 3, 2012·Journal of Neurophysiology·Sung-min ParkKamran Khodakhah
Jul 9, 2020·Proceedings of the National Academy of Sciences of the United States of America·Rosendo G HernándezPablo M Blazquez
Feb 13, 2003·Annals of the New York Academy of Sciences·J I SimpsonB Winkelman
Dec 16, 2005·Journal of Neurophysiology·Beerend Winkelman, Maarten Frens
Aug 9, 2011·The Cerebellum·John I Simpson
Mar 20, 2002·Current Neurology and Neuroscience Reports·J S Stahl, R J Leigh
Aug 19, 2015·The Cerebellum·Robert A HensbroekJohn I Simpson
Jun 7, 2017·The Journal of Physiology·Kai VogesChris I De Zeeuw
Nov 3, 2016·Scientific Reports·Aleksandra BaduraChris I De Zeeuw
Nov 19, 2020·Nature Reviews. Neuroscience·Chris I De Zeeuw
Sep 22, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·C I de ZeeuwJ van den Burg
Feb 13, 2001·Neurobiology of Disease·J C SunC I De Zeeuw
Aug 5, 2021·Journal of Neurophysiology·Alexander S FanningJennifer L Raymond
May 7, 2013·Neuron·Aleksandra BaduraChris I De Zeeuw

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