Phase-sensitive optical low-coherence reflectometry for the detection of analyte concentrations

Applied Optics
Kirill V LarinThomas E Milner

Abstract

Optical techniques may potentially be used for noninvasive glucose sensing. We investigated the application of phase-sensitive optical low-coherence reflectometry (PS-OLCR) to the measurement of analyte concentrations. The dependence of the PS-OLCR signal on the concentration of various analytes, including aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin, were determined in clear and turbid media. Obtained results demonstrated (1) a high degree of sensitivity and accuracy of the phase measurements of analyte concentrations with PS-OLCR; (2) a concentration-dependent change in the phase-shift for glucose that is significantly greater than that of other analytes sampled over the same physiological range; and (3) a high submillimolar sensitivity of PS-OLCR for the measurement of glucose concentration. Further exploration of the application of PS-OLCR to the noninvasive, sensitive, and specific monitoring of glucose concentration seems warranted.

References

Nov 22, 1991·Science·D HuangC A Puliafito
Jan 1, 1997·Lasers in Surgery and Medicine·R BaysH van den Bergh
Mar 23, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Matthew Bartlett, Huabei Jiang
Jun 19, 2003·Physics in Medicine and Biology·Kirill V LarinRinat O Esenaliev
Oct 23, 2003·Lasers in Surgery and Medicine·Taner AkkinThomas E Milner
Dec 7, 2007·Optics Letters·D P Davé, T E Milner
Dec 13, 2007·Optics Letters·C K Hitzenberger, A F Fercher

❮ Previous
Next ❯

Citations

Jan 18, 2014·Sensors·Shih-Hsiang HsuChing-Yu Lin
Aug 2, 2013·The Review of Scientific Instruments·Jitendra SolankiJ T Andrews
Jul 1, 2007·Journal of Diabetes Science and Technology·Roman V KuranovRinat O Esenaliev
Aug 4, 2006·Physics in Medicine and Biology·Roman V KuranovRinat O Esenaliev
Oct 10, 2013·Optics Letters·Norman LippokFrédérique Vanholsbeeck
Sep 2, 2006·Experimental Biology and Medicine·Veronika V SapozhnikovaRinat O Esenaliev
Sep 26, 2013·Lab on a Chip·Eva RyckeboerRoel Baets
Sep 1, 2005·Analytical Chemistry·Mark A Arnold, Gary W Small

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.