Phase Separation in Regulation of Aggrephagy

Journal of Molecular Biology
Daxiao SunLi Yu

Abstract

The selective degradation of protein aggregates is called aggrephagy. Misfolded proteins are thought to form aggregates, which are then surrounded by selective autophagy receptors and targeted to autophagosomes for degradation. Recent studies of p62 bodies, PGL granules, and stress granules indicate that proteins targeted for aggrephagy are not simple protein aggregates but rather form liquid-like protein condensates through liquid-liquid phase separation. The liquid-like properties of the condensates and hardening to a gel-like state may be crucial in the initiation of aggrephagy. Dysregulation of phase separation may cause human diseases. Here we review the potential roles of liquid-liquid phase separation in the process of aggrephagy.

Citations

May 2, 2020·The Journal of Cell Biology·Thomas J MeliaAnne Simonsen
Oct 18, 2020·Cellular and Molecular Life Sciences : CMLS·Weilin XuAnwen Shao
Jan 15, 2021·Current Opinion in Cell Biology·Yuko Fujioka, Nobuo N Noda
May 1, 2021·International Journal of Molecular Sciences·Hong ChenTao Wang
Jun 5, 2021·Cell Chemical Biology·Daiki Takahashi, Hirokazu Arimoto
Jun 18, 2021·Chemical Reviews·Dieter WillboldHenrike Heise
Jun 15, 2021·Molecular Aspects of Medicine·Hui QianWen-Xing Ding

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