Phase separation in three-component lipid membranes: from Monte Carlo simulations to Ginzburg-Landau equations

The Journal of Chemical Physics
Ramon ReigadaKatja Lindenberg

Abstract

Preferential affinity of cholesterol for saturated rather than unsaturated lipids underlies the thermodynamic process of the formation of lipid nanostructures in cell membranes, that is, of rafts. In this context, phase segregation of two-dimensional ternary lipid mixtures is formally studied from two different perspectives. The simplest approach is based on Monte Carlo simulations of an Ising model corresponding to two interconnected lattices, from which the basic features of the phenomenon are investigated. Then, the coarse-graining mean field procedure of the discrete Hamiltonian is adapted and a Ginzburg-Landau-like free energy expression is obtained. From this latter description, we construct kinetic equations that enable us to perform numerical simulations and to establish analytical phase separation criteria. Application of our formalism in the biological context is also discussed.

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Citations

Jul 7, 2011·Quarterly Reviews of Biophysics·Frank L H Brown
Dec 3, 2008·The Journal of Chemical Physics·Jordi GómezRamon Reigada
Aug 26, 2014·The Journal of Chemical Physics·Brian A Camley, Frank L H Brown
Dec 29, 2009·FEBS Letters·Ana J García-Sáez, Petra Schwille
Sep 9, 2008·Biochimica Et Biophysica Acta·Paulo F F Almeida
Jun 27, 2014·Chemistry and Physics of Lipids·Pablo González de Prado SalasPedro Tarazona
Aug 8, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jordi GómezRamon Reigada
Jan 15, 2011·Physical Review Letters·Brian A Camley, Frank L H Brown
May 19, 2009·Chemical Reviews·Shiqi Zhou, J R Solana
May 20, 2021·Physical Review. E·Kayla C SappAlexander J Sodt

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