Phase studies of a urethane model compound and polyether macroglycols by infrared spectroscopy and the relationship between eutectic composition of soft segment and blood compatibility

Journal of Biomedical Materials Research
K IsamaA Nakamura

Abstract

The binary mixtures of a urethane model compound, diethyl 4,4'-methylenebis(N-phenylcarbamate) (MDU), and various polyether macroglycols have been investigated mainly by infrared (IR) spectroscopy. The mixtures of macroglycol and MDU showed two C=O bands (free C=O at higher wave number, hydrogen bonded C=O at lower wave number), and the intensity of free C=O increased while that of hydrogen bonded C=O decreased linearly with increasing molar ratio of macroglycol/MDU. The slope of the increase or decrease suddenly changed at the specific molar ratio around the eutectic composition. The eutectic molar composition for PTMO1000/MDU was determined as 1.15 or 1.1 by differential scanning calorimetry (DSC) or infrared (IR) studies while that for PTMO3000/MDU as 0.345 or 0.55 by DSC or IR, respectively. The eutectic compositions for other sets were determined by IR studies as follows: PEO1000/MDU, 0.4; PEO3000/MDU, 0.16; PPO1000/MDU, 1.4; PPO3000/MDU, 0.45. The number of ethylene oxide, tetramethylene oxide, and propylene oxide units to form a eutectic with MDU calculated from these values were 15-20, 10-11, and 23-24, respectively. The similar DSC or IR changes were observed in the various kinds of polyurethanes such as MDI/BD, MDI/PT...Continue Reading

References

Apr 1, 1987·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Y NakaiM Yamamoto
Sep 1, 1986·Journal of Biomedical Materials Research·N YuiY Sakurai
Feb 1, 1986·Journal of Biomedical Materials Research·R E MarchantA Hiltner
Jan 1, 1972·Transactions - American Society for Artificial Internal Organs·D J LymanB R Mooney

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Citations

Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·P W StottB W Barry
Aug 9, 2012·International Journal of Pharmaceutics·Chun-Woong ParkEun-Seok Park
Dec 13, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J A P DutraJ C O Villanova

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