Phase-transfer catalysed asymmetric synthesis of α-chiral tetrasubstituted α-aminothioesters.

Organic & Biomolecular Chemistry
Yasushi YoshidaMasami Sakamoto

Abstract

Chiral amino thioesters are important scaffolds owing to their widespread use in organic synthesis and biosynthesis. Despite their usefulness, their asymmetric synthesis, especially the catalytic asymmetric synthesis of α-chiral tetrasubstituted α-aminothioesters, is limited, with only one example reported so far. Herein, we report the first phase-transfer catalysed asymmetric synthesis of α-chiral tetrasubstituted α-aminothioesters to afford the corresponding products in up to 81% ee.

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