PMID: 2492905Feb 24, 1989Paper

Phase variation of gonococcal protein II: regulation of gene expression by slipped-strand mispairing of a repetitive DNA sequence

Cell
G L MurphyJ G Cannon

Abstract

Expression of outer membrane protein II (P.II) of Neisseria gonorrhoeae is subject to reversible phase variation at a rate of 10(-3)-10(-4)/cell/generation. The signal peptide coding regions of P.II genes contain variable numbers of tandem repeats of the sequence CTCTT. Changes in the number of CTCTT units, leading to frameshifting within the gene, are responsible for changes in P.II expression. Phase variation mediated by the CTCTT repeat also occurred in E. coli, as assayed with a P.II-alkaline phosphatase (phoA) gene fusion. Phase variation in both the gonococcus and E. coli was recA-independent, occurred at similar rates, and involved insertions or deletions of one or more repeat units. The characteristics of the phase variation process were consistent with a model in which expression of P.II genes is regulated by slipped-strand mispairing of the DNA in the CTCTT repeat region.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Feb 1, 1986·The Journal of Infectious Diseases·P F SparlingM So
Mar 25, 1988·Cell·D BrunierS D Ehrlich
Jan 1, 1985·Molecular & General Genetics : MGG·M MatfieldW J Brammar
Jul 1, 1986·Journal of Bacteriology·R S Schwalbe, J G Cannon
Sep 30, 1988·Science·H Htun, J E Dahlberg
Jan 25, 1988·The Journal of Biological Chemistry·R D Wells
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R M Schaaper, R L Dunn
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C S Hoffman, A Wright
Jul 5, 1985·Journal of Molecular Biology·G von Heijne
Aug 1, 1982·Infection and Immunity·L W Mayer
Mar 1, 1982·Journal of General Microbiology·J L Diaz, J E Heckels
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C Egner, D E Berg
Jul 1, 1982·Infection and Immunity·J Swanson
Jun 1, 1963·Journal of Bacteriology·D S KELLOGGD I PIRKLE

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Citations

Jul 30, 2008·Antonie van Leeuwenhoek·Florence Wisniewski-Dyé, Ludovic Vial
Sep 4, 2012·Bulletin of Mathematical Biology·Benjamin Allen, Daniel I Scholes Rosenbloom
Apr 12, 2007·Journal of Biosciences·Vattipally B SreenuHampapathalu A Nagarajam
Dec 1, 1992·Trends in Genetics : TIG·B D Robertson, T F Meyer
Mar 1, 1991·Immunology Today·P Borst
Feb 26, 1999·Trends in Microbiology·C DehioT F Meyer
Dec 17, 2005·Nature Reviews. Microbiology·Tonje Davidsen, Tone Tønjum
Feb 1, 2012·Nature Reviews. Microbiology·Alison K Criss, H Steven Seifert
May 22, 2001·Molecular Microbiology·A R Richardson, I Stojiljkovic
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D R AllredA F Barbet
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S DawidJ W St Geme
Mar 1, 1994·The Journal of Experimental Medicine·A E JerseJ G Cannon
Sep 9, 1998·The Journal of Experimental Medicine·J P van PuttenJ Carlson
Sep 11, 2003·Proceedings. Biological Sciences·Lauren Ancel MeyersIgor Stojiljkovic
Jun 1, 1991·Molecular Microbiology·E L AhoJ G Cannon
Oct 1, 1991·Molecular Microbiology·R J Belland
Oct 1, 1991·Molecular Microbiology·A BihimaierC P Gibbs
Jul 20, 2004·Clinical Microbiology Reviews·Marjan W van der Woude, Andreas J Bäumler

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