Phaseolotoxin transport in Escherichia coli and Salmonella typhimurium via the oligopeptide permease.

Journal of Bacteriology
B J Staskawicz, N J Panopoulos

Abstract

Phaseolotoxin [(N delta-phosphosulfamyl)ornithylalanylhomoarginine], a phytotoxic tripeptide produced by Pseudomonas syringae pv. phaseolicola that inhibits ornithine carbamoyltransferase, is transported into Escherichia coli and Salmonella typhimurium via the oligopeptide transport system (Opp). Mutants defective in oligopeptide permease (Opp-) were resistant to phaseolotoxin. Spontaneous phaseolotoxin-resistant mutants (Toxr) lacked the Opp function as evidenced by their cross-resistance to triornithine and failure to utilize glycylhistidylglycine as a source of histidine. Growth inhibition by phaseolotoxin was prevented by peptides known to be transported via the Opp system and by treatment of the toxin with L-aminopeptidase. In both E. coli and S. typhimurium, Toxr mutations were cotransducible with trp, suggesting that the opp locus occupies similar positions in genetic maps of these bacteria.

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Citations

Apr 6, 2006·Journal of Bacteriology·Hiroki MorizonoMendel Tuchman
Jan 26, 2007·FEMS Microbiology Letters·Eduardo H NakamatsuLuís C S Ferreira
Apr 7, 2005·Applied and Environmental Microbiology·Jennifer R Walker, Elliot Altman
Jun 30, 2007·Oral Microbiology and Immunology·R S L NepomucenoR C C Ferreira
Aug 3, 2005·FEMS Microbiology Letters·Dongsheng ZhouRuifu Yang
Apr 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manuela MaurerChris Oostenbrink
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