Phasic boosting of medial perforant path-evoked granule cell output time-locked to spontaneous dentate EEG spikes in awake rats

Journal of Neurophysiology
C R Bramham

Abstract

Dentate spikes (DSs) are positive-going field potential transients that occur intermittently in the hilar region of the dentate gyrus during alert wakefulness and slow-wave sleep. The function of dentate spikes is unknown; they have been suggested to be triggered by perforant path input and are associated with firing of hilar interneurons and inhibition of CA3 pyramidal cells. Here we investigated the effect of DSs on medial perforant path (MPP)-granule cell-evoked transmission in freely moving rats. The MPP was stimulated selectively in the angular bundle while evoked field potentials and the EEG were recorded with a vertical multielectrode array in the dentate gyrus. DSs were identified readily on the basis of their characteristic voltage-versus-depth profile, amplitude, duration, and state dependency. Using on-line detection of the DS peak, the timing of MPP stimulation relative to single DSs was controlled. DS-triggered evoked responses were compared with conventional, manually evoked responses in still-alert wakefulness (awake immobility) and, in some cases, slow-wave sleep. Input-output curves were obtained with stimulation on the positive DS peak (0 delay) and at delays of 50, 100, and 500 ms. Stimulation on the peak DS ...Continue Reading

References

May 1, 1978·Journal of Neurophysiology·J Winson, C Abzug
May 1, 1990·Trends in Neurosciences·M Stewart, S E Fox
Jul 1, 1990·Journal of Neurophysiology·W Müller, U Misgeld
Oct 1, 1987·Electroencephalography and Clinical Neurophysiology·S S Suzuki, G K Smith
Jun 1, 1988·Electroencephalography and Clinical Neurophysiology·S S Suzuki, G K Smith
Jun 1, 1988·Electroencephalography and Clinical Neurophysiology·S S Suzuki, G K Smith
Jul 24, 1989·Brain Research·C R Bramham, B Srebro
Nov 29, 1986·Brain Research·G Buzsáki
Nov 3, 1987·Brain Research·B J LeonardC A Barnes
Jan 1, 1971·Experimental Brain Research·P AndersenK K Skrede
Apr 1, 1966·Acta Physiologica Scandinavica·P AndersenP E Voorhoeve
Oct 1, 1983·Brain Research·G BuzsákiC H Vanderwolf
Apr 1, 1980·Experimental Neurology·A P RudellJ B Ranck
Aug 1, 1993·Progress in Neurobiology·B H Bland, L V Colom
Jan 1, 1993·Experimental Brain Research·E J GreenB L McNaughton
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Mar 1, 1997·The European Journal of Neuroscience·A SikG Buzsáki
Nov 1, 1954·Journal of Neurophysiology·J D GREEN, A A ARDUINI

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Citations

Apr 21, 2017·The Journal of Physiology·Miriam S NokiaMarkku Penttonen
Oct 24, 2003·Journal of Neurophysiology·Karl A E Karlsson, Mark S Blumberg
Jul 30, 2004·Journal of Neurophysiology·Laura Lee ColginGary Lynch
Aug 5, 2021·Cell Reports·Dino DvorakAndré Antonio Fenton

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