Phasic non-micturition contractions in the bladder of the anaesthetized and awake rat

BJU International
Tomi StrengJames I Gillespie

Abstract

To characterize the contractile activity that occurs in the bladder during the filling phase of the micturition cycle (non-micturition contractions, NMCs), which generate transient rises in intravesical pressure not associated with urine flow. The experiments were conducted using anaesthetized (chloral hydrate) and un-anaesthetized rats. In un-anaesthetized rats bladder contractile activity was measured using an intravesical cannula implanted under full surgical anaesthesia 3 days previously. In the anaesthetized rats the bladder was exteriorized and a cannula inserted through the dome. In these experiments electrical activity within the detrusor was also measured with a suction electrode on the bladder surface. For each rat, the experimental protocol involved filling the bladder at a constant rate (10 mL/h) to evoke micturition cycles, or infusion of a fixed volume and recording made under effective isovolumetric conditions. In both anaesthetized and un-anaesthetized rats there were transient rises in bladder pressure (0.5-3 cmH2O). In the anaesthetized rats the amplitude of the transients increased throughout the filling phase, with little change in frequency. The phasic NMCs generating these pressure transients were accompan...Continue Reading

References

Nov 1, 1992·Journal of Neurophysiology·C W Vaughan, P M Satchell
Jan 1, 1993·Neurourology and Urodynamics·B L CoolsaetH V De Bakker
Jun 1, 1993·Acta Physiologica Scandinavica·P SatchellC Vaughan
May 1, 1996·British Journal of Obstetrics and Gynaecology·K Heslington, P Hilton
Mar 1, 1996·British Journal of Urology·S E Bristow, D E Neal
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K Sugaya, W C de Groat
Jan 15, 2003·Experimental Physiology·M J DrakeJ I Gillespie
Jun 11, 2003·The Journal of Urology·Marcus J DrakeJames I Gillespie
Jun 28, 1955·The Journal of Physiology·A IGGO
Jun 1, 1959·The American Journal of Physiology·B F HOFFMANH C HERRLICH
Dec 22, 2004·BJU International·Magdalini LagouJames I Gillespie
Apr 21, 2005·BJU International·Marcus J DrakeWim A Van Duyl
Oct 1, 1892·The Journal of Physiology·C S Sherrington

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Citations

Dec 12, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Toshiki HatanakaSeiji Kaku
Mar 9, 2011·Biomechanics and Modeling in Mechanobiology·Rebecca L HeiseMichael S Sacks
Jun 19, 2008·Journal of Molecular Neuroscience : MN·Simon StudenyMargaret A Vizzard
Dec 25, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Birthe SchnegelsbergDebra A Cockayne
Dec 30, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Phillip P SmithGeorge A Kuchel
Jul 25, 2009·American Journal of Physiology. Renal Physiology·Bopaiah P CheppudiraMargaret A Vizzard
Apr 27, 2012·American Journal of Physiology. Renal Physiology·Katarina Zvarova, Peter Zvara
Oct 10, 2008·American Journal of Physiology. Renal Physiology·Mary Beth Klinger, Margaret A Vizzard
Jun 1, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Nadire EserSerpil Önder
Jun 21, 2011·The Journal of Urology·Bart T BiallosterskiStefan G de Wachter
Dec 23, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Mahipal ChoudharyEls van Asselt
Oct 22, 2008·European Journal of Pharmacology·Rainer N PoleyPaul H Ratz
Mar 25, 2008·European Journal of Pharmacology·Hacer Sinem BüyüknacarSerpil Onder
Feb 17, 2015·BJU International·Nadine D HuppertzJoachim O Grosse
Mar 16, 2016·The Journal of General Physiology·Thomas J HeppnerMark T Nelson
Nov 1, 2011·Neurourology and Urodynamics·Jianwen ZengSivert Lindström
Sep 10, 2011·Neurourology and Urodynamics·Masanori NomiyaNorio Takahashi
Dec 25, 2010·Neurourology and Urodynamics·Filip De BockJean-Jacques Wyndaele
Sep 15, 2011·Developmental Neurobiology·Robert W HamillMargaret A Vizzard
Jun 11, 2011·Neurourology and Urodynamics·Karl-Erik AnderssonClaudius Füllhase
Sep 10, 2014·Neurourology and Urodynamics·Francesco ClavicaRon van Mastrigt
Mar 19, 2015·The Journal of Physiological Sciences : JPS·Mahipal ChoudharyFrancesco Clavica
May 26, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·J I GillespieC Korstanje
Aug 7, 2013·Organogenesis·Jane E Eastham, James I Gillespie
Jun 5, 2016·Autonomic Neuroscience : Basic & Clinical·Sara PersynJames Gillespie
Jun 28, 2016·Autonomic Neuroscience : Basic & Clinical·Sara PersynStefan De Wachter
Aug 6, 2016·Neurourology and Urodynamics·Robert S KelleyMichael Brodman
Feb 17, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Monica EggermontJames Gillespie
Nov 28, 2008·BJU International·Steven M FinneyJames I Gillespie
Apr 7, 2009·BJU International·James I GillespieJan de Vente
Dec 11, 2019·Neurourology and Urodynamics·Jerzy B GajewskiMohammad Sajjad Rahnama'i
Jun 6, 2018·Frontiers in Cellular Neuroscience·Céline MeriauxGommert A van Koeveringe

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