Phe(1)Psi(CH(2)-NH)Gly(2)]NC(1-13)NH(2) does not antagonize orphaninFQ/nociceptin-induced prolactin release

Brain Research Bulletin
Winnifred BryantJames Janik

Abstract

The specificity of the orphaninFQ (OFQ)/nociceptin (N)-induced prolactin increase was determined in male and female rats by pretreating animals with different doses of [Phe(1)Psi(CH(2)-NH)Gly(2)]NC(1-13)NH(2), a compound originally reported to be a specific OFQ/N antagonist. In addition, the effect of naloxone pretreatment on OFQ/N-induced prolactin release was examined to determine if OFQ/N's effects were mediated by opiate receptors. Furthermore, dose response studies using [Phe(1)Psi(CH(2)-NH)Gly(2)]NC(1-13)NH(2) only were performed to determine potential agonist activity of this drug. Finally, growth hormone (GH) levels were determined as an index of specificity of the prolactin response. Our results confirm previous findings that OFQ/N potently stimulates prolactin release and that a gender difference exists in the magnitude of the response, with females showing a much greater response than male rats. The endocrine response is specific because OFQ/N potently stimulated prolactin, but not GH secretion. The prolactin response is not mediated by actions at opiate receptors because naloxone did not inhibit OFQ/N's effects on prolactin release. However, [Phe(1)Psi(CH(2)-NH) Gly2]NC(1-13) NH(2) did not antagonize OFQ/N's effects...Continue Reading

References

Feb 1, 1981·Metabolism: Clinical and Experimental·J E Morley
Dec 1, 1994·Clinical Endocrinology·U UlrichW G Rossmanith
Jun 4, 1998·Trends in Neurosciences·T DarlandD K Grandy
Oct 15, 1998·British Journal of Anaesthesia·T Darland, D K Grandy
Mar 17, 1999·Biochemical Pharmacology·M KingG W Pasternak
Apr 1, 2000·British Journal of Pharmacology·G Calo'D Regoli
Apr 25, 2000·Neuroendocrinology·H JarryK Bauer
Sep 22, 2000·Peptides·C Mollereau, L Mouledous
Sep 22, 2000·Peptides·B E HawesD G Lambert
Sep 22, 2000·Peptides·J E Grisel, J S Mogil
Jun 1, 1990·Journal of Neuroendocrinology·M H Baumann, J Rabii

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