PMID: 374708Apr 1, 1979Paper

Phenazines with two cationic side chains as potential antimalarials

Journal of Pharmaceutical Sciences
S N Sawhney, D W Boykin

Abstract

1,9-Phenazine-bis(dialkylaminocarboxamides) were prepared for screening as potential antimalarials. No significant activity against Plasmodium berghei was observed. The phenazine targets were prepared from 1,9-phenazinedicarboxylic acid by standard methods. The reaction between 1,9-phenazinedicarboxylic acid and thionyl chloride in the presence of dimethylformamide unexpectedly gave 4-chloro-1,9-phenazinedicarbonyl chloride.

References

Apr 1, 1977·Journal of Medicinal Chemistry·B P Das, D W Boykin
Feb 2, 1971·Biochemistry·U Hollstein, R J Van Gemert
Jul 28, 1968·Journal of Molecular Biology·W Müller, D M Crothers
Mar 18, 1969·Biochimica Et Biophysica Acta·R A CarchmanI B Weinstein

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Citations

Mar 11, 2004·Chemical Reviews·Jane Buus Laursen, John Nielsen

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