PMID: 1196407Nov 3, 1975Paper

Phencyclidine and ketamine: comparison with the effect of cocaine on the noradrenergic neurones of the rat brain cortex

Naunyn-Schmiedeberg's Archives of Pharmacology
H D TaubeK Starke

Abstract

In slices of rat occipital cortex, the influence of phencyclidine and ketamine on the accumulation of 3H-noradrenaline and the subsequent outflow of tritium was investigated, and was compared with the effect of cocaine.--All three drugs inhibited the accumulation of tritium during incubation of the slices with 3H-noradrenaline. Phencyclidine was slightly, whereas ketamine was much less effective than cocaine.--All three drugs accelerated the spontaneous outflow of tritium from slices preincubated with 3H-noradrenaline. The acceleration caused by low concentrations probably reflects an inhibition of the re-uptake of spontaneously released 3H-noradrenaline; in addition, high concentrations (10(-4) M phencyclidine, 3 X 10(-4)-10(-3) M cocaine and 10(-3)-3 X 10(-3) M ketamine) appear to release tritiated compounds from the neurones. The distance between uptake-inhibiting and releasing concentrations was much greater for cocaine than for phencyclidine and ketamine.--All three drugs enhanced the overflow of tritium evoked by electrical field stimulation. The increase probably reflects an inhibition of the re-uptake of released 3H-noradrenaline; in addition, phencyclidine appears to enhance the release of noradrenaline per pulse.--The...Continue Reading

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Citations

Nov 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·E Schlicker, M Göthert
Aug 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·M Göthert, H Huth
Jan 15, 1988·Biological Psychiatry·L D AldesL A Marco
Dec 9, 1982·Brain Research·J L Stringer, P G Guyenet
Oct 26, 1979·European Journal of Pharmacology·S D GlickR D Meibach
May 2, 1980·European Journal of Pharmacology·S N Raja, P G Guyenet
Jul 17, 1981·European Journal of Pharmacology·S Castellani, P M Adams
Nov 5, 1982·European Journal of Pharmacology·M A Bayorh, I J Kopin
Feb 11, 1986·European Journal of Pharmacology·P C ContrerasT L O'Donohue
Apr 1, 1981·Neuropharmacology·S Castellani, P M Adams
May 1, 1986·Pharmacology, Biochemistry, and Behavior·N E GoedersJ E Smith
Aug 1, 1989·Pharmacology, Biochemistry, and Behavior·N E GoedersK H McAllister
Feb 1, 1986·Neuroscience·M G Lacey, G Henderson
Dec 1, 1982·Annals of Emergency Medicine·J M Felser, D J Orban
Sep 10, 2003·Neurochemistry International·Michelle M TsoJonathan A Stamford
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S R Zukin, R S Zukin
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J P VincentM Lazdunski
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E X AlbuquerqueM P Blaustein
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M P Blaustein, R K Ickowicz
Jul 31, 2001·Journal of Psychoactive Drugs·K L Jansen, R Darracot-Cankovic
Mar 20, 2015·Journal of UOEH·Noriaki SatohNobuyuki Yanagihara
Mar 17, 2006·Journal of Neurochemistry·Prashant Mandela, Gregory A Ordway
Feb 1, 1982·British Journal of Pharmacology·A R GintzlerS R Zukin
Jun 16, 2015·British Journal of Pharmacology·D Lodge, M S Mercier
Jun 1, 2008·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Young-Yeob KoDong-Yoon Lim
Apr 1, 1982·Critical Reviews in Toxicology·O Aniline, F N Pitts
Oct 1, 1993·British Journal of Pharmacology
Jan 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·G GrossH J Schümann
Dec 18, 2020·Pharmacological Reviews·Antonio InserraGabriella Gobbi
Apr 15, 1982·Biochemical Pharmacology·A AmirP Fuchs

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