Phencyclidine-induced disruption of oscillatory activity in prefrontal cortex: Effects of antipsychotic drugs and receptor ligands

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Laia Lladó-PelfortPau Celada

Abstract

The non-competitive NMDA receptor (NMDA-R) antagonist phencyclidine (PCP) markedly disrupts thalamocortical activity, increasing excitatory neuron discharge and reducing low frequency oscillations (LFO, <4Hz) that temporarily group neuronal discharge. These actions are mainly driven by PCP interaction with NMDA-R in GABAergic neurons of the thalamic reticular nucleus and likely underlie PCP psychotomimetic activity. Here we report that classical (haloperidol, chlorpromazine, perphenazine) and atypical (clozapine, olanzapine, quetiapine, risperidone, ziprasidone, aripripazole) antipsychotic drugs--but not the antidepressant citalopram--countered PCP-evoked fall of LFO in the medial prefrontal cortex (mPFC) of anesthetized rats. PCP reduces LFO by breaking the physiological balance between excitatory and inhibitory transmission. Next, we examined the role of different neurotransmitter receptors to reverse PCP actions. D2-R and D1-R blockade may account for classical antipsychotic action since raclopride and SCH-23390 partially reversed PCP effects. Atypical antipsychotic reversal may additionally involve 5-HT1A-R activation (but not 5-HT2A-R blockade) since 8-OH-DPAT and BAYx3702 (but not M100907) fully countered PCP effects. Blo...Continue Reading

References

Feb 22, 1991·Science·T Sawaguchi, P S Goldman-Rakic
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·F A WieselG Sedvall
Feb 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F P BymasterD T Wong
Jan 16, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J Arnt, T Skarsfeldt
Jan 6, 2001·Neuron·D A Lewis, J A Lieberman
Feb 13, 2001·Trends in Cognitive Sciences·A K. Engel, W Singer
Apr 3, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J H Meador-WoodruffV Haroutunian
Oct 1, 2005·The Journal of Comparative Neurology·Paul L A GabbottSarah J Busby
Nov 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Llorenç Díaz-MataixFrancesc Artigas
Jun 22, 2007·International Journal of Geriatric Psychiatry·Martha SajatovicWilliam J Meyer
Sep 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lucila KargiemanFrancesc Artigas
Oct 17, 2008·The American Journal of Psychiatry·David A LewisDebra Montrose
Apr 3, 2009·The Journal of Clinical Investigation·David A Lewis, Robert A Sweet
Jan 12, 2010·Acta Psychiatrica Scandinavica·F Artigas
Jul 21, 2010·Clinical Schizophrenia & Related Psychoses·Philip Seeman
Jul 12, 2011·Expert Opinion on Investigational Drugs·Bjørn H EbdrupBirte Glenthøj
Oct 21, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lucila KargiemanPau Celada
Nov 15, 2011·Molecular Neurobiology·M Victoria Puig, Allan T Gulledge
Sep 19, 2012·Schizophrenia Bulletin·Joseph T Coyle
Apr 30, 2013·Frontiers in Integrative Neuroscience·Pau CeladaFrancesc Artigas
Aug 9, 2013·JAMA Psychiatry·René S Kahn, Richard S E Keefe
Jul 21, 2014·Biological Psychiatry·Eva Troyano-RodriguezFrancesc Artigas
Mar 24, 2015·ACS Chemical Neuroscience·M Victoria Puig, Thomas Gener

❮ Previous
Next ❯

Citations

Nov 5, 2016·Nature Reviews. Drug Discovery·Francesc ArtigasAdam J Schwarz
Aug 12, 2016·Journal of Cellular Physiology·Rahul MittalXue Zhong Liu
May 13, 2019·Experimental Brain Research·Paul J Fitzgerald, Brendon O Watson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.