PMID: 22216506Aug 1, 1976

Phenelzine in urine: assay and relation to acetylator status

British Journal of Clinical Pharmacology
B CaddyE C Johnstone

Abstract

Phenelzine cannot be extracted as such from biological fluids. Formation of the acetonide derivative prior to extraction allows phenelzine to be extracted and assayed by gas chromatography at levels down to 0.5 microg/ml. At this sensitivity the drug can be detected in urine but not in plasma, after therapeutic doses. Persons typed as slow acetylators of sulphadimidine excreted approximately twice as much unmetabolized phenelzine in urine compared to fast acetylators.

References

Oct 1, 1975·British Journal of Clinical Pharmacology·A Fine, D J Sumner
Mar 17, 1973·Lancet·E C Johnstone, W Marsh
Dec 1, 1969·Journal of Medical Genetics·D A Evans
Aug 13, 1960·British Medical Journal·D A EvansV A McKUSICK
Jul 1, 1965·Clinical Pharmacology and Therapeutics·D A EvansR T PRATT

Citations

Feb 28, 1979·Psychopharmacology·W J TilstoneE C Johnstone
Jan 1, 1989·Pharmacology & Therapeutics·D A Evans
Aug 1, 1978·British Journal of Clinical Pharmacology·B CaddyE C Johnstone
Aug 1, 1984·Journal of Medical Genetics·D A Evans
Aug 1, 1981·British Journal of Clinical Pharmacology·A L Harris, N McIntyre

Related Concepts

Acetylation
Thymoleptics
Chromatography, Gas-Liquid
Nardelzine
Analogs & derivatives
Body Fluids
Gas Chromatography
Phenelzine
Plasma
Sulfamethazine

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