Phenethyl Isothiocyanate and Cisplatin Co-Encapsulated in a Liposomal Nanoparticle for Treatment of Non-Small Cell Lung Cancer

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Mengwei SunAnthony J Di Pasqua

Abstract

Lung cancer is the leading cause of cancer-related death in the Unites States, and approximately 85% of all lung cancers are classified as non-small cell lung cancer (NSCLC), which is extremely difficult to treat and its survival rate is low. After decades of clinical trials, the most effective treatments are still those that implement the first-generation platinum anticancer agent cisplatin (CDDP) in combination with other drugs. We previously demonstrated that the naturally-occurring compound phenethyl isothiocyanate (PEITC) can be used to sensitize NSCLC cells to CDDP. Furthermore, co-encapsulation of PEITC and CDDP in liposomes enhances their toxicity toward NSCLC cells. We here optimize liposomal-PEITC-CDDP, demonstrate the release of PEITC and CDDP from the nanoparticle, and show that liposomal-PEITC-CDDP is much more toxic toward both A549 and H596 human NSCLC cell lines than toward WI-38 and BEAS-2B human normal lung cell lines. Thus, we have prepared an efficacious therapy that has significantly higher toxicity toward cancer cell lines than normal cell lines.

References

Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin J van den Bent
May 16, 2008·Biometrical Journal. Biometrische Zeitschrift·Torsten HothornPeter Westfall
Jun 6, 2008·The Journal of Biological Chemistry·Lixin MiFung-Lung Chung
Jan 27, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·John GoffinUNKNOWN Lung Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-Based Care
May 5, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G P StathopoulosG Tsoukalas
Aug 17, 2010·Chemical Research in Toxicology·Anthony J Di PasquaFung-Lung Chung
Oct 5, 2010·Nature Reviews. Drug Discovery·Charles Dumontet, Mary Ann Jordan
Feb 9, 2011·Cancer Chemotherapy and Pharmacology·G P StathopoulosP Michalopoulou
May 20, 2011·Molecular Nutrition & Food Research·Xiantao WangFung-Lung Chung
Aug 5, 2011·Accounts of Chemical Research·Wafa' T Al-Jamal, Kostas Kostarelos
Apr 25, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Younghyun LeeHai Won Chung

❮ Previous
Next ❯

Citations

Mar 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shaoming JinFazheng Ren
Dec 31, 2019·Pharmaceutical Frontiers·Max KullbergHolly A Martinson
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomhiro MastuoHideki Sakai
Sep 22, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Xia LiWei Chen
Jan 21, 2021·Pharmaceutics·Ositomiwa O OsipitanAnthony J Di Pasqua
Mar 13, 2021·Free Radical Biology & Medicine·Qi Wang, Yongping Bao
Jun 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xinglong FanJun Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
dynamic light scattering

Software Mentioned

car
R
leveneTest
Excel
multcomp

Related Concepts